J
Joshua D. Rabinowitz
Researcher at Princeton University
Publications - 418
Citations - 53550
Joshua D. Rabinowitz is an academic researcher from Princeton University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 102, co-authored 385 publications receiving 42192 citations. Previous affiliations of Joshua D. Rabinowitz include Stanford University & University of Pennsylvania.
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Journal ArticleDOI
Quantification of NADPH balance during adipogenesis
TL;DR: Using isotope tracers and flux analysis, NADPH production routes in adipocytes are examined, using isotopeTracer and fluxAnalysis, for the first time to examine the pathways used to make NADPH under different physiological circumstances.
ReportDOI
Integration of Carbon, Nitrogen, and Oxygen Metabolism in Escherichia coli--Final Report
TL;DR: In this paper, the authors investigated the link between the metabolism of different nutrients, quantified metabolic responses to nutrient perturbations using LC-MS based metabolomics and built differential equation models that bridge multiple nutrient systems.
Journal ArticleDOI
Optimal methods for re-ordering data matrices in systems biology and drug discovery applications
Peter A. DiMaggio,Scott R. McAllister,Christodoulos A. Floudas,Xiao Jiang Feng,Joshua D. Rabinowitz,Herschel Rabitz +5 more
TL;DR: This article presents rigorous clustering methods based on the optimal re-ordering of data matrices, which can be used in an iterative framework to bicluster data and assist in the synthesis of drug compounds.
Journal ArticleDOI
Abstract CT549: Randomized Phase II trial of two different nutritional approaches for patients receiving treatment for their advanced pancreatic cancer
Diana L. Hanna,Gayle S. Jameson,Drew W. Rasco,Angela Tatiana Alistar,Richard C. Frank,Anthony B. El-Khoueiry,Julia E. Wiedmeier,Caroline G. P. Roberts,Brandon Fell,Sarah Hallberg,Denise J. Roe,Derek Cridebring,Joshua D. Rabinowitz,Stephen T. Gately,Daniel D. Von Hoff +14 more
TL;DR: A ketogenic diet combined with triplet chemotherapy was shown to inhibit murine pancreatic KPC tumor growth and to triple the survival benefit of chemotherapy alone and was associated with glucose depletion, altered TCA substrate usage, and NADH elevation.
Journal ArticleDOI
Oxidative stress induces lysosomal membrane permeabilization and ceramide accumulation in retinal pigment epithelial cells.
Kevin Zhang,Connor Jankowski,Rayna Marshall,Rohini M. Nair,Néstor Gómez,Ahab Alnemri,Yingrui Liu,Elizabeth A. Erler,Julia Ferrante,Ying-ru Song,Brent A. Bell,Bailey Baumann,Jacob Sterling,Brandon Anderson,Sierra Foshe,J Roof,Hossein Fazelinia,Lynn A. Spruce,Jen-Zen Chuang,Ching-Hwa Sung,Anuradha Dhingra,Kathleen Boesze-Battaglia,Venkata R M Chavali,Joshua D. Rabinowitz,Claire H. Mitchell,Joshua L. Dunaief +25 more
TL;DR: In this article , the authors used cell culture and mouse models of iron overload, as iron can catalyze reactive oxygen species formation in the retinal pigment epithelial (RPE) cells playing a key role.