Joshua D. Rabinowitz

TL;DR: A Peak Annotation and Verification Engine (PAVE) is introduced for annotating untargeted microbial metabolomics data with only ∼4% of peaks annotated as apparent metabolites.

TL;DR: Knowing of enzyme-catalyzed H-D exchange between water and NADPH enables accurate interpretation of deuterium tracing studies of redox cofactor and fatty acid metabolism, and shows D2O labels fatty acids primarily via NADPH.

TL;DR: In this article, a heat-conductive substrate is used to produce a drug composition film containing a therapeutically effective dose of a drug when the drug is administered in aerosol form.

TL;DR: This work presents a global network optimization approach, NetID, to annotate untargeted LC-MS metabolomics data, and identifies a half-dozen novel metabolites, including thiamine and taurine derivatives.

TL;DR: It is demonstrated that fructose induces lipogenesis when its dietary intake rate exceeds the intestinal clearance capacity, andModulating the capacity of the intestinal epithelium to catabolize fructose is shown to alter fructose-induced lipogenesis in the mouse liver, suggesting that fructose clearance in the small intestine protects from steatosis.