J
Joshua D. Rabinowitz
Researcher at Princeton University
Publications - 418
Citations - 53550
Joshua D. Rabinowitz is an academic researcher from Princeton University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 102, co-authored 385 publications receiving 42192 citations. Previous affiliations of Joshua D. Rabinowitz include Stanford University & University of Pennsylvania.
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Journal ArticleDOI
LC-MS and GC-MS based metabolomics platform for cancer research
Wenyun Lu,Sisi Zhang,Sisi Zhang,Xin Teng,Eugene Melamud,Mitchell A. Lazar,Eileen White,Joshua D. Rabinowitz,Joshua D. Rabinowitz +8 more
TL;DR: A LC-MS and GC-MS based analytical platform for the comprehensive analysis of cellular metabolites, including water-soluble metabolites, and waterinsoluble fatty acids, and phospholipids is presented.
Posted ContentDOI
The Metabolites NADP+ and NADPH are the Targets of the Circadian Protein Nocturnin (Curled)
Michael A. Estrella,Jin Du,Li Chen,Sneha Rath,Eliza Prangley,Alisha Chitrakar,Tsutomu Aoki,Paul Schedl,Joshua D. Rabinowitz,Alexei Korennykh +9 more
TL;DR: Evidence for NOCT targeting to mitochondria is provided and it is proposed that NADP(H) regulation, which takes place at least in part in mitochondria, establishes the molecular link between circadian clock and metabolism.
Journal ArticleDOI
Inhibition of de novo pyrimidine synthesis augments Gemcitabine induced growth inhibition in an immunocompetent model of pancreatic cancer.
Thuy Phan,Vu H. Nguyen,Ralf Buettner,Corey Morales,Lifeng Yang,Paul Wong,Weiman Tsai,Marcela d'Alincourt Salazar,Ziv Gil,Don J. Diamond,Joshua D. Rabinowitz,Steven D. Rosen,Laleh G. Melstrom +12 more
TL;DR: In this article, the authors evaluated the efficacy and changes in the tumor microenvironment of Lef monotherapy and in combination with Gem, in a syngeneic mouse model of pancreatic cancer.
Journal ArticleDOI
CAR T-Cells Depend on the Coupling of NADH Oxidation with ATP Production
Juan Carlos García-Cañaveras,David Heo,Sophie Trefely,John Leferovich,Chong Xu,Benjamin Philipson,Saba Ghassemi,Michael C. Milone,Edmund K. Moon,Nathaniel W. Snyder,Nathaniel W. Snyder,Carl H. June,Joshua D. Rabinowitz,Roddy S. O’Connor +13 more
TL;DR: In this article, the enzyme Lactobacillus brevis NADH Oxidase (LbNOX), which mimics the oxidative function of the electron transport chain without generating ATP, was shown to promote CAR T-cell metabolic activity and antitumor efficacy.
Journal ArticleDOI
A tps1Δ persister-like state in Saccharomyces cerevisiae is regulated by MKT1.
Patrick A. Gibney,Patrick A. Gibney,Anqi Chen,Ariel Schieler,Jonathan C. Chen,Yi-Fan Xu,David G. Hendrickson,R. Scott McIsaac,Joshua D. Rabinowitz,David Botstein +9 more
TL;DR: Observations are corroborated that a small fraction of yeast tps1Δ cells do grow on glucose, unlike the majority of the population, and it is shown that this phenomenon is glucose-specific, as it does not occur on another highly fermented carbon source, fructose.