J
Joshua E. Burda
Researcher at University of California, Los Angeles
Publications - 17
Citations - 3876
Joshua E. Burda is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Astrocyte & Spinal cord injury. The author has an hindex of 13, co-authored 14 publications receiving 2835 citations. Previous affiliations of Joshua E. Burda include University of Rochester & Mayo Clinic.
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Journal ArticleDOI
Astrocyte scar formation aids central nervous system axon regeneration
Mark Anderson,Joshua E. Burda,Yilong Ren,Yan Ao,Timothy M. O’Shea,Riki Kawaguchi,Giovanni Coppola,Baljit S. Khakh,Timothy J. Deming,Michael V. Sofroniew +9 more
TL;DR: Interestingly, RNA sequencing revealed that astrocytes and non-astrocyte cells in SCI lesions express multiple axon-growth-supporting molecules, showing that contrary to the prevailing dogma, astroCyte scar formation aids rather than prevents central nervous system axon regeneration.
Journal ArticleDOI
Reactive gliosis and the multicellular response to CNS damage and disease.
TL;DR: The contributions of diverse nonneuronal cell types to outcome after acute injury, or to the progression of chronic disease, are of increasing interest as the push toward understanding and ameliorating CNS afflictions accelerates.
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Astrocyte roles in traumatic brain injury.
TL;DR: Evidence regarding astrocyte contribution to post-traumatic tissue repair and synaptic remodeling is examined, and the potential for targeting specific aspects of astrogliosis to ameliorate TBI sequelae is considered.
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Cell biology of spinal cord injury and repair
TL;DR: Spinal cord injury (SCI) lesions present diverse challenges for repair strategies, and the emerging understanding of how SCI cell biology differs across lesion compartments is fundamental to developing rationally targeted repair strategies.
Journal ArticleDOI
Required growth facilitators propel axon regeneration across complete spinal cord injury
Mark Anderson,Mark Anderson,Timothy M. O’Shea,Joshua E. Burda,Yan Ao,Sabry L. Barlatey,Alexander M. Bernstein,Jae H. Kim,Nicholas D. James,Alexandra Rogers,Brian Kato,Alexander L. Wollenberg,Riki Kawaguchi,Giovanni Coppola,Chen Wang,Timothy J. Deming,Zhigang He,Grégoire Courtine,Michael V. Sofroniew +18 more
TL;DR: Overcoming the failure of axon regrowth across anatomically complete SCI lesions after maturity required the combined sequential reinstatement of several developmentally essential mechanisms that facilitate axon growth.