Z
Zhigang He
Researcher at Boston Children's Hospital
Publications - 164
Citations - 25723
Zhigang He is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Axon & Regeneration (biology). The author has an hindex of 67, co-authored 150 publications receiving 22194 citations. Previous affiliations of Zhigang He include Massachusetts Institute of Technology & Stanford University.
Papers
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Journal ArticleDOI
Glial inhibition of CNS axon regeneration
Glenn Yiu,Zhigang He +1 more
TL;DR: The molecular basis of inhibitory molecules in CNS myelin as well as proteoglycans associated with astroglial scarring are evaluated and their contributions to the limitation of long-distance axon repair and other types of structural plasticity are evaluated.
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Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway
Kevin K. Park,Kai Liu,Yang Hu,Patrice D. Smith,Chen Wang,Bin Cai,Bengang Xu,Lauren Connolly,Ioannis Kramvis,Mustafa Sahin,Zhigang He +10 more
TL;DR: The manipulation of intrinsic growth control pathways as a therapeutic approach to promote axon regeneration after CNS injury is suggested.
Journal ArticleDOI
Neuropilin Is a Receptor for the Axonal Chemorepellent Semaphorin III
Zhigang He,Marc Tessier-Lavigne +1 more
TL;DR: Evidence is provided that neuropilin is a receptor or a component of a receptor complex that mediates the effects of Sema III on these axons, and that antibodies to neuro pilin block the ability ofSema III to repel sensory axons and to induce collapse of their growth cones.
Journal ArticleDOI
Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates.
Luca Tamagnone,Stefania Artigiani,Hang Chen,Zhigang He,Guo Li Ming,Hongjun Song,Alain Chédotal,Margaret L. Winberg,Corey S. Goodman,Mu-ming Poo,Marc Tessier-Lavigne,Paolo M. Comoglio +11 more
TL;DR: It is concluded that plexins are receptors for multiple (and perhaps all) classes of semaphorins, either alone or in combination with neuropilins, and trigger a novel signal transduction pathway controlling cell repulsion.
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Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth.
Kevin C. Wang,Vuk Koprivica,Jieun Kim,Rajeev Sivasankaran,Yong Guo,Rachel L. Neve,Rachel L. Neve,Zhigang He +7 more
TL;DR: It is shown that a glycosylphosphatidylinositol-anchored CNS myelin protein, oligodendrocyte-myelin glycoprotein (OMgp), is a potent inhibitor of neurite outgrowth in cultured neurons and that Interfering with the OMgp/NgR pathway may allow lesioned axons to regenerate after injury in vivo.