J
Joshua J. Wang
Researcher at State University of New York System
Publications - 51
Citations - 2984
Joshua J. Wang is an academic researcher from State University of New York System. The author has contributed to research in topics: Unfolded protein response & Endoplasmic reticulum. The author has an hindex of 26, co-authored 45 publications receiving 2548 citations. Previous affiliations of Joshua J. Wang include University of Oklahoma & University at Buffalo.
Papers
More filters
Journal ArticleDOI
Pigment epithelium-derived factor (PEDF) is an endogenous antiinflammatory factor
TL;DR: It is suggested that PEDF is a novel endogenous anti‐inflammatory factor in the eye, and the decrease of ocular PEDf levels may contribute to inflammation and vascular leakage in DR.
Journal ArticleDOI
Pigment epithelium-derived factor downregulates vascular endothelial growth factor (VEGF) expression and inhibits VEGF-VEGF receptor 2 binding in diabetic retinopathy.
TL;DR: The present study demonstrated that there is a reciprocal interaction between VEGF and PEDF in the retina, and inhibited hypoxia-induced increases in VEGf promoter activity, HIF-1 nuclear translocation and mitogen activated protein kinase phosphorylation, suggesting that the reciprocal regulation between V EGF andPEDF may play a role in angiogenic control.
Journal ArticleDOI
Endoplasmic Reticulum Stress is implicated in Retinal Inflammation and Diabetic Retinopathy
TL;DR: Inhibition of ER stress by chemical chaperone 4‐phenyl butyric acid ameliorated inflammation in cultured human retinal endothelial cells exposed to hypoxia, and in the retinas of diabetic and OIR mice, indicating that ER stress is a potential mediator of retinal inflammation in diabetic retinopathy.
Journal ArticleDOI
Inhibition of Reactive Oxygen Species by Lovastatin Downregulates Vascular Endothelial Growth Factor Expression and Ameliorates Blood-Retinal Barrier Breakdown in db/db Mice: Role of NADPH Oxidase 4
TL;DR: Activation of Nox4 plays an important role in high-glucose– and hypoxia-mediated VEGF expression and diabetes-induced BRB breakdown and, at least in part, contributes to the protective effects of lovastatin in diabetic retinopathy.
Journal ArticleDOI
ER Stress and Apoptosis: A New Mechanism for Retinal Cell Death
TL;DR: Recent progress on ER stress and apoptosis in retinal diseases is summarized, focusing on various proapoptotic and antiapoptosis pathways that are activated by the UPR, and how these pathways contribute to ER stress-induced apoptosisIn retinal cells.