Kai Chen

TL;DR: It is demonstrated that nicotinamide adenine dinucleotide phosphate reduced oxidase 4 (Nox4), a major Nox isoform expressed in nonphagocytic cells, including vascular endothelium, is localized to the endoplasmic reticulum (ER), indicating that the specificity of intracellular ROS-mediated signal transduction may be modulated by the localization of Noxisoforms within specific subcellular compartments.

TL;DR: Findings implicate increased mitochondrial fission as a contributing mechanism for endothelial dysfunction in diabetic states through increased reactive oxygen species production.

TL;DR: Data indicate that H2O2 promotes calcium-dependent eNOS activity through a coordinated change in the phosphorylation status of the enzyme mediated by Src- and ErbB receptor-dependent PI 3-K activation.

TL;DR: It is suggested that induction of HO‐1 by pharmacological means may be a novel approach to amelioration of oxidative insults to neurons.

TL;DR: The data are consistent with a metabolic model in which malonyl-CoA mediates the switch from fatty acid catabolism to lipid synthesis during glucose stimulation of beta-cells, and it is suggested that these changes in lipid metabolism could play a pivotal role in the regulation of the sustained phase of insulin secretion.