J
Joshua J. Ziarek
Researcher at Indiana University
Publications - 42
Citations - 1349
Joshua J. Ziarek is an academic researcher from Indiana University. The author has contributed to research in topics: Chemokine receptor & G protein-coupled receptor. The author has an hindex of 19, co-authored 34 publications receiving 1175 citations. Previous affiliations of Joshua J. Ziarek include University of Wisconsin–Whitewater & Harvard University.
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Journal ArticleDOI
Monomeric and dimeric CXCL12 inhibit metastasis through distinct CXCR4 interactions and signaling pathways.
Luke J. Drury,Joshua J. Ziarek,Stéphanie Gravel,Christopher T. Veldkamp,Christopher T. Veldkamp,Tomonori Takekoshi,Samuel T Hwang,Nikolaus Heveker,Brian F. Volkman,Michael B. Dwinell +9 more
TL;DR: It is shown that administration of CXCL12 extended survival of tumor-bearing mice by potently limiting metastasis of colorectal carcinoma or murine melanoma and concluded that cellular migration is tightly regulated by selective CXCR4 signaling evoked by unique interactions with distinct ligand quaternary structures.
Journal ArticleDOI
Structure-based ligand discovery for the protein-protein interface of chemokine receptor CXCR4.
Michael M. Mysinger,Dahlia R. Weiss,Joshua J. Ziarek,Stéphanie Gravel,Allison K. Doak,Joel Karpiak,Nikolaus Heveker,Brian K. Shoichet,Brian F. Volkman +8 more
TL;DR: The potency and efficiency of these molecules has few precedents among protein–protein interface inhibitors, and supports structure-based efforts to discover leads for chemokine GPCRs.
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New paradigms in chemokine receptor signal transduction: moving beyond the two-site model
Andrew B. Kleist,Anthony E. Getschman,Joshua J. Ziarek,Amanda M. Nevins,Pierre-Arnaud Gauthier,Andy Chevigné,Martyna Szpakowska,Brian F. Volkman +7 more
TL;DR: New paradigms in CKR signal transduction are explored by considering studies that depict a more intricate architecture governing the consequences of chemokine-CKR interactions, within a rapidly changing landscape in which CKR signaling is influenced by receptor PTMs, chemokin and CKR dimerization, and endogenous non-chemokine ligands.
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Heparin Oligosaccharides Inhibit Chemokine (CXC Motif) Ligand 12 (CXCL12) Cardioprotection by Binding Orthogonal to the Dimerization Interface, Promoting Oligomerization, and Competing with the Chemokine (CXC Motif) Receptor 4 (CXCR4) N Terminus
Joshua J. Ziarek,Christopher T. Veldkamp,Fuming Zhang,Nathan J. Murray,Gabriella A. Kartz,Xinle Liang,Jidong Su,John E. Baker,Robert J. Linhardt,Brian F. Volkman +9 more
TL;DR: It is found that co-administration of heparin abrogated the protective effect of CXCL12 in an ex vivo rat heart model for myocardial infarction and the structural basis for GAG recognition by CxCL12 is clarified and insight is lent into the development of C XCL12-based therapeutics.
Journal ArticleDOI
The CXC Chemokine Receptor 4 Ligands Ubiquitin and Stromal Cell-derived Factor-1α Function through Distinct Receptor Interactions
Vikas Saini,Daniel M. Staren,Joshua J. Ziarek,Zayd N. Nashaat,Edward M. Campbell,Brian F. Volkman,Adriano Marchese,Matthias Majetschak +7 more
TL;DR: Evidence is provided that ubiquitin and the cognate CXCR4 ligand stromal cell-derived factor (SDF)-1α do not share CX CR7 as a receptor, and it is demonstrated that Ubiquitin does not utilize the typical two-site binding mechanism of chemokine-receptor interactions.