Alginate: properties and biomedical applications

Hydrogel delivery systems can leverage therapeutically beneficial outcomes of drug delivery and have found clinical use. Hydrogels can provide spatial and temporal control over the release of various therapeutic agents, including small-molecule drugs, macromolecular drugs and cells. Owing to their tunable physical properties, controllable degradability and capability to protect labile drugs from degradation, hydrogels serve as a platform in which various physiochemical interactions with the encapsulated drugs control their release. In this Review, we cover multiscale mechanisms underlying the design of hydrogel drug delivery systems, focusing on physical and chemical properties of the hydrogel network and the hydrogel-drug interactions across the network, mesh, and molecular (or atomistic) scales. We discuss how different mechanisms interact and can be integrated to exert fine control in time and space over the drug presentation. We also collect experimental release data from the literature, review clinical translation to date of these systems, and present quantitative comparisons between different systems to provide guidelines for the rational design of hydrogel delivery systems.

/pdf/designing-hydrogels-for-controlled-drug-delivery-3k03j5j2j9.pdf

Designing hydrogels for controlled drug delivery.

Alginate derivatization: a review of chemistry, properties and applications.

Antibacterial adhesive injectable hydrogels with rapid self-healing, extensibility and compressibility as wound dressing for joints skin wound healing.

A review on polymeric hydrogel membranes for wound dressing applications: PVA-based hydrogel dressings

https://cmapspublic3.ihmc.us/rid=1266358861321_2027852911_13457/Wound%20Healing%20Dressings%20and%20Drug%20Delivery%20Systems.pdf

Wound healing dressings and drug delivery systems: a review.

Advanced Therapeutic Dressings for Effective Wound Healing—A Review

Over the last three decades industrial adaptability has allowed hot-melt extrusion (HME) to gain wide acceptance and has already established its place in the broad spectrum of manufacturing operations and pharmaceutical research developments. HME has already been demonstrated as a robust, novel technique to make solid dispersions in order to provide time controlled, modified, extended, and targeted drug delivery resulting in improved bioavailability as well as taste masking of bitter active pharmaceutical ingredients (APIs). This paper reviews the innumerable benefits of HME, based on a holistic perspective of the equipment, processing technologies to the materials, novel formulation design and developments, and its varied applications in oral drug delivery systems.

/pdf/a-review-of-hot-melt-extrusion-process-technology-to-li4ppgb6r0.pdf

A Review of Hot-Melt Extrusion: Process Technology to Pharmaceutical Products

https://pureadmin.qub.ac.uk/ws/files/149927725/3D_printed_microneedles_for_insulin_skin_delivery.pdf

Joshua S. Boateng

Papers

Wound healing dressings and drug delivery systems: a review.

Advanced Therapeutic Dressings for Effective Wound Healing—A Review

A Review of Hot-Melt Extrusion: Process Technology to Pharmaceutical Products

3D printed microneedles for insulin skin delivery

Polyox and carrageenan based composite film dressing containing anti-microbial and anti-inflammatory drugs for effective wound healing