J
Joshua S. Harbort
Researcher at University of Queensland
Publications - 8
Citations - 94
Joshua S. Harbort is an academic researcher from University of Queensland. The author has contributed to research in topics: Catalysis & Chemistry. The author has an hindex of 3, co-authored 5 publications receiving 28 citations.
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Journal ArticleDOI
Understanding the Mechanistic Requirements for Efficient and Stereoselective Alkene Epoxidation by a Cytochrome P450 Enzyme
T. Coleman,Alicia M. Kirk,Rebecca R. Chao,M.N. Podgorski,Joshua S. Harbort,Luke R. Churchman,John B. Bruning,Paul V. Bernhardt,Jeffrey Harmer,Elizabeth H. Krenske,James J. De Voss,Stephen Bell +11 more
TL;DR: The cytochrome P450 (CYP) family of heme monooxygenase enzymes commonly catalyzes enantioselective hydroxylation and epoxidation reactions.
Journal ArticleDOI
Biophysical Techniques for Distinguishing Ligand Binding Modes in Cytochrome P450 Monooxygenases.
M.N. Podgorski,Joshua S. Harbort,T. Coleman,Jeanette E. Stok,Jake A. Yorke,Luet-Lok Wong,John B. Bruning,Paul V. Bernhardt,James J. De Voss,Jeffrey Harmer,Stephen Bell +10 more
TL;DR: The crystal structures of CYP199A4, with the pyridinyl com-pounds bound, revealed that while the nitrogen of 4-Methoxybenzoic acid is coordinated to the heme, with 4-(pyridin-3-yl)benzosic acid an aqua ligand remains, and correlation between binding modes, spectroscopic properties and the ob-served biochemical activity is measured.
Journal ArticleDOI
Elucidating the mechanism of the Ley–Griffith (TPAP) alcohol oxidation
Timothy J. Zerk,Peter W. Moore,Joshua S. Harbort,Sharon Chow,Lindsay T. Byrne,George A. Koutsantonis,Jeffrey Harmer,Manuel Martínez,Craig M. Williams,Paul V. Bernhardt +9 more
TL;DR: The mechanism of the Ley–Griffith alcohol oxidation has been elucidated using time-resolved spectroscopic methods.
An Altered Heme Environment in an Engineered Cytochrome P450 Enzyme Enables the Switch from Monooxygenase to Peroxygenase Activity
M.N. Podgorski,Joshua S. Harbort,Joel H. Z. Lee,Giang Nguyen,John B. Bruning,William A. Donald,Paul V. Bernhardt,Jeffrey Harmer,Stephen Bell +8 more
Journal ArticleDOI
From 0 to II in One-Electron Steps: A Series of Ruthenium Complexes Supported by TropPPh2.
Xiuxiu Yang,Thomas L. Gianetti,Joshua S. Harbort,Michael Wörle,Lilin Tan,Lilin Tan,Cheng-Yong Su,Pascal Jurt,Jeffrey Harmer,Hansjörg Grützmacher,Hansjörg Grützmacher +10 more
TL;DR: EPR data of the mononuclear Ru(I) complex reveal couplings of the unpaired spin with the ruthenium and two phosphorus nuclei, as well as the olefinic protons which show that the spin is mainly localized on the Ru( I) center.