Josival Emanuel Ferreira Alves

TL;DR: The present review aims at showing through distinct biological tests the performance of different candidates to anticancer drugs and their respective chemical modifications, which are crucial and/or determinant for DNA affinity and inhibition of important enzymes in cells' vital processe to either separately or synergistically optimize anticancer activity.

TL;DR: In this review, the drugs that have been repurposed so far are grouped according to their chemical class to provide better understanding of their structural similarities and possible correlations with mechanisms of actions that can help identifying anti-SARS-CoV-2 promising therapeutic agents.

TL;DR: In this paper, the authors reported the synthesis of eight novel indole-thiazole derivatives, as well as their ability to interact with DNA, analysed through the UV-vis absorption, fluorescence, circular dichroism (CD), viscosity techniques and molecular docking.

TL;DR: In silico studies showed that all derivatives used in this research displayed good oral bioavailability potential and protein-ligand interactions, as well as the antitopoisomerase potential of these compounds.

TL;DR: There is an increasing tendency to use albumin in analyses of absorption, distribution, metabolism and excretion (ADME) properties of anticancer molecules, which further demonstrated the promising character of this investigation for proposing new drugs.