J
Joyce Chen
Researcher at California Institute of Technology
Publications - 11
Citations - 1706
Joyce Chen is an academic researcher from California Institute of Technology. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 5, co-authored 7 publications receiving 1234 citations. Previous affiliations of Joyce Chen include University of California & La Jolla Institute for Allergy and Immunology.
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Journal ArticleDOI
Antibody-based protection against HIV infection by vectored immunoprophylaxis
TL;DR: It is shown that humanized mice receiving VIP appear to be fully protected from HIV infection, even when challenged intravenously with very high doses of replication-competent virus, suggesting that successful translation of this approach to humans may produce effective prophylaxis against HIV.
Journal ArticleDOI
NR4A transcription factors limit CAR T cell function in solid tumours.
Joyce Chen,Isaac F. López-Moyado,Isaac F. López-Moyado,Hyungseok Seo,Chan-Wang J. Lio,Laura J. Hempleman,Takashi Sekiya,Akihiko Yoshimura,James P. Scott-Browne,Anjana Rao +9 more
TL;DR: Transfer of NR4A-deficient T cells expressing chimeric antigen receptors is shown to reduce tumour burden and increase survival by shifting T cell transcriptional programs away from exhaustion and towards increased effector function.
Journal ArticleDOI
TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8+ T cell exhaustion
Hyungseok Seo,Joyce Chen,Joyce Chen,Edahí González-Avalos,Edahí González-Avalos,Daniela Samaniego-Castruita,Daniela Samaniego-Castruita,Arundhoti Das,Yueqiang H. Wang,Isaac F. López-Moyado,Isaac F. López-Moyado,Romain O. Georges,Wade Zhang,Wade Zhang,Atsushi Onodera,Atsushi Onodera,Cheng-Jang Wu,Li-Fan Lu,Patrick G. Hogan,Patrick G. Hogan,Avinash Bhandoola,Anjana Rao +21 more
TL;DR: The high-mobility group (HMG)-box transcription factors TOX and TOX2, as well as members of the NR4A family of nuclear receptors, are targets of the calcium/calcineurin-regulated transcription factor NFAT, even in the absence of its partner AP-1 (FOS-JUN).
Journal ArticleDOI
Vectored immunoprophylaxis protects humanized mice from mucosal HIV transmission
Alejandro B. Balazs,Yong Ouyang,Christin M. Hong,Christin M. Hong,Joyce Chen,Steven M Nguyen,Dinesh S. Rao,Dong Sung An,David Baltimore +8 more
TL;DR: It is demonstrated that VIP is capable of protecting humanized mice from intravenous as well as vaginal challenge with diverse HIV strains despite repeated exposures, suggesting that VIP may be effective in preventing vaginal transmission of HIV between humans.
Journal ArticleDOI
Vectored immunoprophylaxis protects humanized mice from mucosal HIV transmission.
TL;DR: It is demonstrated that VIP is capable of protecting humanized mice from intravenous as well as vaginal challenge with diverse viral strains, despite repeated exposures, suggesting that VIP may be effective in preventing vaginal transmission of HIV between humans.