Joyce E. Royland

TL;DR: Altered patterns of gene expression during critical windows of brain development indicate that thyroid disease must be viewed as a continuum and that conditions typically considered ‘subclinical’ may induce structural and functional abnormalities in the developing central nervous system.

TL;DR: The results indicate that diet/O3 did not have a global effect on brain OS parameters, but showed some brain region- and OS parameter-specific effects by diets.

TL;DR: Changes associated with age were more pronounced with enzyme activities declining as the animals aged, which may aid in evaluating brain bioenergetic impact on the age-related susceptibility to environmental chemical stressors.

TL;DR: Polybrominated diphenyl ethers (PBDEs) are structurally similar to polychlorinated biphenyls (PCBs) and have both central (learning and memory deficits) and peripheral dysfunctio...

TL;DR: The genomic data suggests that PCB-induced neurotoxic effects were due to disruption of normal ontogenetic pattern of nervous system growth and development by altering intracellular signaling pathways but not by endocrine disruption.