Mary E. Gilbert

TL;DR: Four new lines of research comprise compelling evidence that exposures to Pb have adverse effects on the nervous system, that environmental factors increase nervous system susceptibility to P b, and that exposures in early life may cause neurodegeneration in later life.

TL;DR: Empirical, preclinical and animal research has clearly identified the critical role of TH in brain development and additional work is required to understand the impact of low level perturbations of the thyroid axis to evaluate the risk associated with environmental contaminants with thyroid action.

TL;DR: Although NMDA-mediated potentiation may facilitate kindling, synaptic potentiation does not appear to be a critical requirement for kindling to develop, and the notion that development of the burst response and not synaptic enhancement may be the critical physiological alteration that underlies the kindling phenomenon is supported.

TL;DR: It is demonstrated that moderate degrees of thyroid hormone insufficiency during the early postnatal period permanently alters interneuron expression of PV and compromises inhibitory function in the hippocampus.

TL;DR: D dose-dependent reductions in synaptic transmission and impairments in long-term potentiation of the EPSP component of the compound field potential are revealed and extend observations associated with dentate gyrus synaptic function to a lower dose range and provide correlative evidence of behavioral disruption in a hippocampal-dependent learning task following developmental thyroid hormone insufficiency.