J
Joyce J. Repa
Researcher at University of Texas Southwestern Medical Center
Publications - 100
Citations - 24047
Joyce J. Repa is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Liver X receptor & Cholesterol. The author has an hindex of 54, co-authored 100 publications receiving 22419 citations. Previous affiliations of Joyce J. Repa include University of Wisconsin System & University of Wisconsin-Madison.
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Journal ArticleDOI
Identification of a Nuclear Receptor for Bile Acids
Makoto Makishima,Arthur Y. Okamoto,Joyce J. Repa,Hua Tu,R. Marc Learned,Alvin Luk,Mitchell V. Hull,Kevin D. Lustig,David J. Mangelsdorf,Bei Shan +9 more
TL;DR: Results presented here show that bile acids are physiological ligands for the farnesoid X receptor (FXR), an orphan nuclear receptor, which demonstrates a mechanism by which bile acid transcriptionally regulate their biosynthesis and enterohepatic transport.
Journal ArticleDOI
Nuclear receptors and lipid physiology: opening the X-files.
TL;DR: Some general principles that govern the actions of this class of bioactive lipids and their nuclear receptors are considered here, and the scheme that emerges reveals a complex molecular script at work.
Journal ArticleDOI
Role of LXRs in control of lipogenesis
Joshua R. Schultz,Hua Tu,Alvin Luk,Joyce J. Repa,Julio C. Medina,Leping Li,Susan Schwendner,Shelley Wang,Martin Thoolen,David J. Mangelsdorf,Kevin D. Lustig,Bei Shan +11 more
TL;DR: The identification here of a synthetic, nonsteroidal LXR-selective agonist series represented by T0314407 and T0901317 revealed a novel physiological role of LXR, and suggested that the increase in plasma lipids occurs via NXR-mediated induction of the sterol regulatory element-binding protein 1 (SREBP-1) lipogenic program.
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Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ
Joyce J. Repa,Guosheng Liang,Jiafu Ou,Yuriy Bashmakov,Jean-Marc A. Lobaccaro,Iichiro Shimomura,Bei Shan,Michael S. Brown,Joseph L. Goldstein,David J. Mangelsdorf +9 more
TL;DR: A novel LXR target is described, the sterol regulatory element-binding protein-1c gene (SREBP-1C), which encodes a membrane-bound transcription factor of the basic helix-loop-helix-leucine zipper family and reveals a unique regulatory interplay between cholesterol and fatty acid metabolism.
Journal ArticleDOI
Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis
Takeshi Inagaki,Mihwa Choi,Antonio Moschetta,Li Peng,Carolyn L. Cummins,Jeffrey G. McDonald,Guizhen Luo,Stacey A. Jones,Bryan Goodwin,James A. Richardson,Robert D. Gerard,Joyce J. Repa,David J. Mangelsdorf,Steven A. Kliewer +13 more
TL;DR: It is demonstrated that fibroblast growth factor 15 signals from intestine to liver to repress the gene encoding cholesterol 7alpha-hydroxylase (CYP7A1), which catalyzes the first and rate-limiting step in the classical bile acid synthetic pathway.