Li Peng

TL;DR: It is demonstrated that fibroblast growth factor 15 signals from intestine to liver to repress the gene encoding cholesterol 7alpha-hydroxylase (CYP7A1), which catalyzes the first and rate-limiting step in the classical bile acid synthetic pathway.

TL;DR: Findings reveal a central role for FXR in protecting the distal small intestine from bacterial invasion and suggest that FXR agonists may prevent epithelial deterioration and bacterial translocation in patients with impaired bile flow.

TL;DR: In vitro and in vivo results show that LRH-1 plays an essential role in the maintenance of Oct4 expression in ES cells at the epiblast stage of embryonic development, thereby maintaining pluripotence at this crucial developmental stage prior to segregation of the primordial germ cell lineage at gastrulation.

TL;DR: It is demonstrated that fibroblast growth factor-15, a hormone made by the distal small intestine in response to bile acids, is required for gallbladder filling and suggested that a postprandial timing mechanism that controls gallbladders motility is suggested.

TL;DR: Results indicate that one wall of the PXR ligand-binding cavity can remain flexible even when the receptor is in complex with an activating ligand, highlighting the key role that structural flexibility plays in PxR's promiscuous response to xenobiotics.