J
József Kökösi
Researcher at Semmelweis University
Publications - 61
Citations - 877
József Kökösi is an academic researcher from Semmelweis University. The author has contributed to research in topics: Protonation & Rutaecarpine. The author has an hindex of 16, co-authored 61 publications receiving 820 citations. Previous affiliations of József Kökösi include Hungarian Academy of Sciences & University of Toledo.
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Journal ArticleDOI
Microscopic Protonation/Deprotonation Equilibria of the Anti‐Inflammatory Agent Piroxicam
Krisztina Takács-Novák,József Kökösi,Benjamin Podányi,Béla Noszál,Ruey-Shiuan Tsai,Giuseppe Lisa,Pierre-Alain Carrupt,Bernard Testa +7 more
TL;DR: In this article, the microscopic ionization behavior of piroxicam was investigated using two different approaches, i.e., direct UV spectroscopy and an indirect analogue approach (deductive method).
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Triprotic site-specific acid-base equilibria and related properties of fluoroquinolone antibacterials.
TL;DR: The studies show that the fluoroquinolones have three protonation centers: the carboxylate group, the N-1' and N-4' piperazine nitrogens and concentration of the uncharged microspecies is way below the values published earlier, which could be well interpreted in terms of structural properties.
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A PAMPA Study of the Permeability‐Enhancing Effect of New Ceramide Analogues
TL;DR: Recent results in a project aiming to improve the prediction of transdermal penetration are presented, showing the strongest effect on permeability was caused by the ceramide analogue CTR(C12–C16).
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Nitrogen bridgehead compounds part 16. Facile total synthesis of 7,8-dihydro-13H-indolo[2′,3′:3,4]pyrido[2,1-b]quinazolin-5-one (Rutecarpine).
TL;DR: In this article, a solvent dependent E-Z isomerism was shown for Rutecarpine from hydrazone 2, in high yield by Fischer indole synthesis, and it was shown that the solvent-dependent EZ-isomerism can be achieved with either benzenediazonium chloride or phenylhydrazine.
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Nitrogen bridgehead compounds. 66. Bronchodilator nitrogen bridgehead compounds with a pyrimidinone moiety.
István Hermecz,Lelle Vasvári-Debreczy,Agnes Horvath,Maria Balogh,József Kökösi,Christine DeVos,Ludovic Rodriguez +6 more
TL;DR: New types of bronchodilator agents, bi- and tricyclic nitrogen bridgehead compounds with a pyrimidin-4(3H)-one ring, were synthesized and evaluated for bronchidilator activity against serotonin-, histamine-, and acetylcholine-induced spasms in the guinea pig Konzett-Rössler test.