Juan A. Squella

Abstract: 1,4-dihydropyridine derivatives constitute an important pharmacological group for the treatment of cardiovascular diseases. We have synthesised a series 4-(5'-nitro-2'-furyl)-1,4-dihydropyridine derivatives, which were characterised by 1H-NMR. We have found that carboethoxy groups at the C-3 and C-5 on the 1,4-dihydropyridine ring show a much more complex signal in the 1H NMR spectra, either when C-4 is a pseudo-prochiral or a chiral centre.

TL;DR: In this paper, C4-phenolic-1, 4-dihydropyridines were used for the characterization of title compounds on glassy carbon electrode (GCE) and reactivity with superoxide radical anion.

TL;DR: In this paper, a comprehensive study of the electrochemical characteristics of 2-, 3-, and 4-nitroanisole isomers in three different electrolytic media has been carried out.

TL;DR: In this paper, the electroreduction of a series of nitro-1,4-dihydropyridines has been studied in mixed media and Voltammetric (polarography and cyclic voltammetry) and chromatographic studies, showed that these compounds were transformed into their corresponding hydroxylamine derivatives at the end of the electrolysis.

TL;DR: Computerized simulation with DIGISIM 2.0 of the proposed mechanisms fitted very well with the experimental results for both the natural decay of the radical and its reaction with the tested compounds.