Showing papers by "Juan M. Feliu published in 1997"
TL;DR: In this article, a simple model for simulating the electrooxidation of HCOOH on single crystal surfaces of Pt catalyzed by adatoms is presented, where the substrate is represented as a square or hexagonal array of lattic...
Abstract: A simple model for simulating the electrooxidation of HCOOH on single crystal surfaces of Pt catalyzed by adatoms is presented. The substrate is represented as a square or hexagonal array of lattic...
168 citations
TL;DR: In this article, the combination of uracil and tegafur (UFT) with leucovorin (LV) was shown to be effective and well tolerated in patients with advanced colorectal carcinoma.
Abstract: BACKGROUND
In spite of the high prevalence of cancer in the elderly, little information is available about the efficacy and toxicity of chemotherapy in elderly patients. In a previous study, the authors demonstrated that the combination of uracil and tegafur (UFT) with leucovorin (LV) was active and well tolerated in patients with advanced colorectal carcinoma (ACC). The objective of the current study was to determine the efficacy and toxicity of this regimen in elderly patients with ACC.
METHODS
Thirty-eight unselected patients older than 70 years (median age, 74 years) with measurable ACC were included. All patients were evaluable for toxicity and response. The regimen consisted of intravenous LV 500 mg/m2 on Day 1, oral LV 15 mg every 12 hours on Days 2-14, and oral UFT 390 mg/m2 on Days 1-14. Treatment was repeated every 28 days for a minimum of 4 courses per patient.
RESULTS
Two hundred eighty-eight cycles of chemotherapy were delivered (median, 7 per patient). Two patients (5%) achieved a complete response and 9 (24%) a partial response, for an overall response rate of 29%. Toxicity was mild, without dose-limiting myelosuppression. Four patients (10%) experienced Grade 3-4 diarrhea, 1 patient had Grade 3-4 nausea/vomiting, and 1 had Grade 3-4 mucositis. Grade 3-4 toxicity was more frequent among women than men (38% vs. 4%, P < 0.05).
CONCLUSIONS
Treatment with oral UFT modulated with LV is effective, well tolerated, and feasible on an outpatient basis for elderly patients with ACC. However, elderly women should be followed closely for the early detection of toxicity. Cancer 1997; 79:1884-9. © 1997 American Cancer Society.
66 citations
TL;DR: In this article, the electrooxidation of CO saturated adlayers has been studied on three different rhodium electrodes: Rh(111), Rh(554), and electrochemically disordered rh(111) It has been found that the kinetics of the CO stripping process is senstive to the long-range order of the (111) domains.
46 citations
TL;DR: In this paper, a combination of cyclic voltammetry, charge displacement, and Fourier transform IR spectroscopy was used to characterize the urea adlayers formed at the surface of Pt(100) electrodes immersed in urea-containing solutions.
Abstract: The urea adlayers formed at the surface of Pt(100) electrodes immersed in urea-containing solutions have been characterized in-situ with a combination of cyclic voltammetry, charge displacement, and Fourier transform IR spectroscopy experiments. The infrared data indicate that the urea molecule is bonded through the two nitrogen atoms with the C−O group normal to the electrode surface. At the same time, the cyclic voltammetry and charge displacement data agree with previously reported coverage data if urea adsorption takes place with a net transfer of two electrons per adsorbed urea molecule. The existence of lateral interactions between neighbouring adsorbed molecules has been determined from the analysis of the band frequency and bandwidth together with their dependence on both the urea coverage and the electrode potential. At constant urea coverage the adsorbate band is shifted towards higher wavenumbers as the electrode potential increases, with a measured tuning rate of 50 cm-1 V-1, which does not de...
34 citations
TL;DR: In this article, two statistical models are proposed intending to account for the inhibitory behavior of the HER, one based on the existence of two types of sites on the modified substrate: active (normal) and completely deactivated, whereas the second model also considers infected sites, i.e., partially active sites.
31 citations
TL;DR: Stable, irreversibly adsorbed Pt(100)−Br adlayers composed of discharged bromine atoms can be formed through vapor or electrolyte dosage, can survive emersion, and can be studied in electrolytic media as mentioned in this paper.
Abstract: Stable, irreversibly adsorbed Pt(100)−Br adlayers composed of discharged bromine atoms can be formed through vapor or electrolyte dosage. They survive emersion, can be studied in electrolytic media...
31 citations
TL;DR: In this paper, a Pt(111)−(√3 × √3)R30°−As adlayer structure has been imaged by STM on emersed samples, with an ideal coverage of 0.33 As/Pt.
25 citations
TL;DR: In this paper, the adsorption and oxidation reactions of squaric acid (SQA) at platinum single crystal electrodes with basal orientations have been studied by combining voltammetric and in situ FTR experiments.
18 citations
TL;DR: The electrochemical behavior of Pt(100) electrodes of immersed in semicarbazide containing acidic solutions has been studied by means of cyclic voltammetry and in situ FTIR spectroscopy.
12 citations
6 citations