J
Juan P. Casas
Researcher at VA Boston Healthcare System
Publications - 237
Citations - 29858
Juan P. Casas is an academic researcher from VA Boston Healthcare System. The author has contributed to research in topics: Population & Genome-wide association study. The author has an hindex of 78, co-authored 217 publications receiving 26495 citations. Previous affiliations of Juan P. Casas include Veterans Health Administration & Industrial University of Santander.
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Journal ArticleDOI
Plasma concentrations of asymmetric dimethylarginine (ADMA) in Colombian women with pre-eclampsia.
Renke Maas,Rainer H. Böger,Edzard Schwedhelm,Juan P. Casas,Patricio Lopez-Jaramillo,Norma C. Serrano,Luis A. Diaz +6 more
TL;DR: The sample size had a greater than 93% power to detect a 40% difference in plasma ADMA concentrations with P<.05 (2-sided) used to determine statistical significance and all women enrolled provided written informed consent.
Journal ArticleDOI
Endothelial nitric oxide synthase gene polymorphism (Glu298Asp) and development of pre-eclampsia: a case-control study and a meta-analysis
C. K. H. Yu,Juan P. Casas,Makrina D. Savvidou,Manpreet K Sahemey,Kypros H. Nicolaides,Aroon D. Hingorani +5 more
TL;DR: From the data currently available, the eNOS Glu298Asp polymorphism is not associated with a significant increased risk of pre-eclampsia, however, published studies have been underpowered and larger studies are needed to confirm or refute a realistic genotypic risk of disease.
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Angiotensin-converting enzyme I/D polymorphism and preeclampsia risk: evidence of small-study bias.
Norma C. Serrano,Luis A. Diaz,María C Paez,Clara M. Mesa,Rodrigo Cifuentes,Alvaro Monterrosa,Adriana González,Liam Smeeth,Aroon D. Hingorani,Juan P. Casas,Juan P. Casas +10 more
TL;DR: It is highly likely that the observed small nominal increase in risk of preeclampsia associated with the ACE D-allele is due to small-study bias, similar to that observed in cardiovascular disease.
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Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk
Fotios Drenos,Philippa J. Talmud,Juan P. Casas,Liam Smeeth,Jutta Palmen,Steve E. Humphries,Aroon D. Hingorani +6 more
TL;DR: SNPs indexing biomarkers provide new tools for investigating biological relationships and causal links with disease, and linking genomic with transcriptomic, proteomic and metabolomic analysis, as well as clinical events could better delineate CHD causing pathways amenable to treatment.
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The Latin American Consortium of Studies in Obesity (LASO)
Leonelo E. Bautista,Juan P. Casas,Victor M. Herrera,J. Jaime Miranda,Pablo Perel,Rafael N. Pichardo,Armando E. Gonzalez,José R. Sánchez,Catterina Ferreccio,Ximena Aguilera,Egle Silva,Myriam Oróstegui,Luis Fernando Gómez,Julio A. Chirinos,Josefina Medina-Lezama,Cynthia M. Pérez,Erick Suárez,Ana P. Ortiz,L Rosero,N Schapochnik,Zulma Ortiz,Daniel Ferrante +21 more
TL;DR: Results from LASO will be instrumental to inform health policies aiming to curtail the epidemic of obesity in the region and foster the development of collaborative obesity research among Latin American investigators.