J
Juan Sandoval
Researcher at Epigenomics AG
Publications - 108
Citations - 6903
Juan Sandoval is an academic researcher from Epigenomics AG. The author has contributed to research in topics: DNA methylation & Epigenetics. The author has an hindex of 37, co-authored 100 publications receiving 5838 citations. Previous affiliations of Juan Sandoval include German Cancer Research Center & Université catholique de Louvain.
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Journal ArticleDOI
Validation of a DNA methylation microarray for 450,000 CpG sites in the human genome.
Juan Sandoval,Holger Heyn,Sebastian Moran,Jordi Serra-Musach,Miguel Angel Pujana,Marina Bibikova,Manel Esteller +6 more
TL;DR: It is demonstrated that the 450K DNA methylation array can consistently and significantly detect CpG methylation changes in the H CT-116 colorectal cancer cell line in comparison with normal colon mucosa or HCT-116 cells with defective DNA methyltransferases (DKO).
Journal ArticleDOI
Cancer epigenomics: beyond genomics.
TL;DR: Recent advances in the field of cancer epigenomics concerning DNA methylation, histone modifications, and miRNAs are described, which will be used to generate novel biomarkers of relevance to diagnosis, prognosis, and chemotherapeutic response.
Journal ArticleDOI
Age-dependent epigenetic control of differentiation inhibitors is critical for remyelination efficiency
Siming Shen,Juan Sandoval,Victoria A. Swiss,Jiadong Li,Jeff Dupree,Robin J.M. Franklin,Patrizia Casaccia-Bonnefil,Patrizia Casaccia-Bonnefil +7 more
TL;DR: It is suggested that inefficient epigenetic modulation of the oligodendrocyte differentiation program contributes to the age-dependent decline in remyelination efficiency.
Journal ArticleDOI
DNA methylation contributes to natural human variation
Holger Heyn,Sebastian Moran,Irene Hernando-Herraez,Sergi Sayols,Antonio Gomez,Juan Sandoval,Dave Monk,Kenichiro Hata,Tomas Marques-Bonet,Tomas Marques-Bonet,Liewei Wang,Manel Esteller,Manel Esteller +12 more
TL;DR: In this article, the contribution of DNA methylation patterns to variability in human variation was investigated, and it was found that one third of the differences were not associated with any genetic variation, suggesting that variation in population-specific sites takes place at the genetic and epigenetic levels.
Journal ArticleDOI
A Prognostic DNA Methylation Signature for Stage I Non–Small-Cell Lung Cancer
Juan Sandoval,Jesus Mendez-Gonzalez,Ernest Nadal,Guoan Chen,F. Javier Carmona,Sergi Sayols,Sebastian Moran,Holger Heyn,Miguel Vizoso,Antonio Gomez,Montse Sanchez-Cespedes,Yassen Assenov,Fabian Müller,Christoph Bock,Miquel Taron,Josefina Mora,Lucia Anna Muscarella,Triantafillos Liloglou,Michael P.A. Davies,Marina Pollán,Maria J. Pajares,W. Torre,Luis M. Montuenga,Elisabeth Brambilla,John K. Field,Luca Roz,Marco Lo Iacono,Giorgio V. Scagliotti,Rafael Rosell,David G. Beer,Manel Esteller +30 more
TL;DR: The DNA methylation signature of NSCLC affects the outcome of stage I patients, and it can be practically determined by user-friendly polymerase chain reaction assays.