J
Juan Tan
Researcher at Nankai University
Publications - 52
Citations - 689
Juan Tan is an academic researcher from Nankai University. The author has contributed to research in topics: Transactivation & Virus. The author has an hindex of 13, co-authored 46 publications receiving 565 citations. Previous affiliations of Juan Tan include Chinese Ministry of Education.
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Journal ArticleDOI
Design, synthesis and antiviral activity of novel quinazolinones.
Ziwen Wang,Mingxiao Wang,Xue Yao,Yue Li,Juan Tan,Lizhong Wang,Wentao Qiao,Yunqi Geng,Yuxiu Liu,Qingmin Wang +9 more
TL;DR: A series of quinazolinones were designed and synthesized as novel HIV-1 inhibitors and found to exhibit good anti-TMV activity, of which compo und 9a showed similar in vivo anti- TMV activity to commercial plant virucide Ribavirin.
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HIV-1 Vpr stimulates NF-κB and AP-1 signaling by activating TAK1
TL;DR: HIV-1 Vpr enhances the phosphorylation and polyubiquitination of TAK1, and as a result, activates NF-κB and AP-1 signaling pathways and stimulates HIV-1 LTR promoter.
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IFP35 Is Involved in the Antiviral Function of Interferon by Association with the Viral Tas Transactivator of Bovine Foamy Virus
TL;DR: It is reported that IFP35, a member of the IFP family with a molecular mass of 35 kDa, can interact with the bovine Tas regulatory protein of bovines foamy virus and arrest viral replication and repress viral transcription.
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An isoquinoline alkaloid from the Chinese herbal plant Corydalis yanhusuo W.T. Wang inhibits P-glycoprotein and multidrug resistance-associate protein 1.
TL;DR: Study of effects of glaucine, an alkaloid component of YHS, on P-gp and MRP1 in resistant cancer cells found that it is a substrate and inhibits P- gp andMRP1 competitively and suppresses expression of ABC transporter genes.
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Tetherin inhibits prototypic foamy virus release
TL;DR: It is found that tetherin of human, simian, bovine or canine origin inhibits the production of infectious prototypic foamy virus (PFV); this inhibition is antagonized by HIV-1 Vpu.