J
Judith Lacoste
Researcher at McGill University
Publications - 22
Citations - 1587
Judith Lacoste is an academic researcher from McGill University. The author has contributed to research in topics: Metadata & Interferon. The author has an hindex of 11, co-authored 20 publications receiving 1450 citations. Previous affiliations of Judith Lacoste include Jewish General Hospital.
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Journal ArticleDOI
Characterization of a functional NF-kappa B site in the human interleukin 1 beta promoter: evidence for a positive autoregulatory loop.
John Hiscott,J Marois,J Garoufalis,M. D'addario,Anne Roulston,I Kwan,Normand Pepin,Judith Lacoste,H Nguyen,G Bensi +9 more
TL;DR: The IL-1 beta gene may be considered as an important additional member of the family of cytokine genes regulated in part by the NF-kappa B/rel family of transcription factors.
Journal ArticleDOI
Live-cell microscopy – tips and tools
TL;DR: With an efficient optical microscope and a good detector, the light exposure can be minimized during live-cell imaging, thus minimizing phototoxicity and maintaining cell viability.
Journal ArticleDOI
Dissociation of a MAVS/IPS-1/VISA/Cardif-IKKepsilon molecular complex from the mitochondrial outer membrane by hepatitis C virus NS3-4A proteolytic cleavage.
Rongtuan Lin,Judith Lacoste,Peyman Nakhaei,Qiang Sun,Long Yang,Suzanne Paz,Peter Wilkinson,Ilkka Julkunen,Damien Vitour,Eliane F. Meurs,John Hiscott +10 more
TL;DR: It is demonstrated that NS3-4A cleavage of MAVS/IPS-1/VISA/Cardif/K1271 results in its dissociation from the mitochondrial membrane and disrupts signaling to the antiviral immune response.
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RIG-I-Mediated Antiviral Signaling Is Inhibited in HIV-1 Infection by a Protease-Mediated Sequestration of RIG-I
Mayra Solis,Peyman Nakhaei,Peyman Nakhaei,Mohammad Jalalirad,Judith Lacoste,Renée N. Douville,Renée N. Douville,Meztli Arguello,Tiejun Zhao,Michael Laughrea,Mark A. Wainberg,Mark A. Wainberg,John Hiscott,John Hiscott +13 more
TL;DR: A novel PR-dependent mechanism employed by HIV-1 to counteract the early IFN response to viral RNA in infected cells is revealed.
Journal ArticleDOI
Vascular endothelial growth factor and signaling in the prostate: more than angiogenesis ☆
Simone Chevalier,I Defoy,I Defoy,Judith Lacoste,Lucie Hamel,Lucie Hamel,L Guy,L.R Bégin,Armen Aprikian +8 more
TL;DR: In cloning tyrosine kinase genes in dog prostate cells, a fragment of the vascular endothelial growth factor (VEGF) receptor 1 or Flt-1 was sequenced and a confined staining in chromogranin A and/or serotonin positive neuroendocrine cells was revealed, including in primary tumors and lymph node metastases.