R
Rongtuan Lin
Researcher at McGill University
Publications - 114
Citations - 7640
Rongtuan Lin is an academic researcher from McGill University. The author has contributed to research in topics: Interferon & Interferon regulatory factors. The author has an hindex of 52, co-authored 114 publications receiving 6813 citations. Previous affiliations of Rongtuan Lin include Jewish General Hospital.
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Journal ArticleDOI
The NEMO adaptor bridges the nuclear factor-kappaB and interferon regulatory factor signaling pathways.
TL;DR: It is demonstrated that virus-induced activation of IRF3 and IRF7 depended on the NF-κB modulator NEMO, which acted 'upstream' of the kinases TBK1 and IKKε, andIRF3 phosphorylation and interferon production were restored by ectopic expression of NemO.
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Dissociation of a MAVS/IPS-1/VISA/Cardif-IKKepsilon molecular complex from the mitochondrial outer membrane by hepatitis C virus NS3-4A proteolytic cleavage.
Rongtuan Lin,Judith Lacoste,Peyman Nakhaei,Qiang Sun,Long Yang,Suzanne Paz,Peter Wilkinson,Ilkka Julkunen,Damien Vitour,Eliane F. Meurs,John Hiscott +10 more
TL;DR: It is demonstrated that NS3-4A cleavage of MAVS/IPS-1/VISA/Cardif/K1271 results in its dissociation from the mitochondrial membrane and disrupts signaling to the antiviral immune response.
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Methylation of Tat by PRMT6 Regulates Human Immunodeficiency Virus Type 1 Gene Expression
Marie Chloé Boulanger,Chen Liang,Rodney S. Russell,Rongtuan Lin,Mark T. Bedford,Mark A. Wainberg,Stéphane Richard +6 more
TL;DR: It is demonstrated that arginine methylation of Tat negatively regulates its transactivation activity and that PRMT6 acts as a restriction factor for HIV replication.
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Cellular oxidative stress response controls the antiviral and apoptotic programs in dengue virus-infected dendritic cells.
David Olagnier,Suraj Peri,Courtney Steel,Nadine van Montfoort,Cindy Chiang,Vladimir Beljanski,Michael Slifker,Zhong He,Carmen N. Nichols,Rongtuan Lin,Siddharth Balachandran,John Hiscott +11 more
TL;DR: It is demonstrated that the level of oxidative stress is critical to the control of both antiviral and apoptotic programs in DENV-infected human Mo-DC and highlight the importance of redox homeostasis in the outcome of DENV infection.
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MasterCARD: a priceless link to innate immunity
TL;DR: A novel role for the mitochondria and for caspase activation and recruitment domain (CARD)-containing proteins in coordinating immune and apoptotic responses is highlighted.