Judith P. Kelly

TL;DR: In any given week, most US adults take at least 1 medication, and many take multiple agents; the substantial overlap between use of prescription medications and herbals/supplements raises concern about unintended interactions.

TL;DR: Risks were increased for trimethoprim–sulfamethoxazole and other sulfonamide antibiotics, chlormezanone, quinolones, and aminopenicillins among drugs usually used for short periods.

TL;DR: The use of antibacterial sulfonamides, anticonvulsant agents, oxicam NSAIDs, allopurinol, chlormezanone, and corticosteroids is associated with large increases in the risk of Stevens-Johnson syndrome or toxic epidermal necrolysis, but for none of the drugs does the excess risk exceed five cases per million users per week.

TL;DR: Use of low doses of enteric-coated or buffered aspirin carries a three-fold increase in the risk of major UGIB, suggesting the assumption that these formulations are less harmful than plain aspirin may be mistaken.

TL;DR: SJS and TEN are associated with short-term therapy with phenytoin, phenobarbital, and carbamazepine, and the association with valproic acid seems to be confounded by concomitant short- term therapy with other causal drugs.