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Neil H. Shear
Researcher at Sunnybrook Health Sciences Centre
Publications - 452
Citations - 18806
Neil H. Shear is an academic researcher from Sunnybrook Health Sciences Centre. The author has contributed to research in topics: Toxic epidermal necrolysis & Terbinafine. The author has an hindex of 67, co-authored 443 publications receiving 17172 citations. Previous affiliations of Neil H. Shear include University of British Columbia & University of Toronto.
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Journal ArticleDOI
Clinical classification of cases of toxic epidermal necrolysis, Stevens-Johnson syndrome, and erythema multiforme
Sylvie Bastuji-Garin,Berthold Rzany,Robert S. Stern,Neil H. Shear,Luigi Naldi,Jean-Claude Roujeau +5 more
TL;DR: This study suggests that an illustrated atlas is a useful tool for standardizing the diagnosis of acute severe bullous disorders that are attributed to drugs or infectious agents.
Journal ArticleDOI
Medication use and the risk of Stevens-Johnson syndrome or toxic epidermal necrolysis
J.-C. Roujeau,Judith P. Kelly,Luigi Naldi,B. Rzany,Robert S. Stern,Theresa E. Anderson,Ariane Auquier,Sylvie Bastuji-Garin,Osvaldo Correia,F. Locati,Maja Mockenhaupt,C Paoletti,Samuel Shapiro,Neil H. Shear,Erwin Schöpf,David Kaufman +15 more
TL;DR: The use of antibacterial sulfonamides, anticonvulsant agents, oxicam NSAIDs, allopurinol, chlormezanone, and corticosteroids is associated with large increases in the risk of Stevens-Johnson syndrome or toxic epidermal necrolysis, but for none of the drugs does the excess risk exceed five cases per million users per week.
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Use of selective serotonin-reuptake inhibitors or tricyclic antidepressants and risk of hip fractures in elderly people
Barbara Liu,Geoff Anderson,Nicole Mittmann,Teresa To,Tami Axcell,Neil H. Shear,Neil H. Shear +6 more
TL;DR: Exposure to any of the three classes of antidepressants is associated with a significant increase in the risk of hip fracture, and despite differences in dose distribution, this analysis suggests that SSRIs do not offer an advantage over TCAs in terms of risk of Hip fracture.
Journal ArticleDOI
Differences in metabolism of sulfonamides predisposing to idiosyncratic toxicity.
TL;DR: Susceptibility to sulfonamide reactions may be due to interaction of metabolic pathways, possibly under genetic control, regulating N-acetylation and specific detoxification of toxic metabolites of the drugs.
Journal ArticleDOI
Idiosyncratic drug reactions: the reactive metabolite syndromes
TL;DR: Research is needed to explore further the pathophysiology of idiosyncratic drug reactions, so that better diagnostic tests and treatment methods can be developed.