J
Judith Weber
Researcher at University of Cambridge
Publications - 12
Citations - 1115
Judith Weber is an academic researcher from University of Cambridge. The author has contributed to research in topics: Molecular imaging & Thioflavin. The author has an hindex of 7, co-authored 11 publications receiving 801 citations.
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Journal ArticleDOI
Contrast agents for molecular photoacoustic imaging
TL;DR: The physical, chemical and biochemical characteristics of the existing photoacoustic contrast agents are critically reviewed, highlighting key applications and present challenges for molecular PAI.
Journal ArticleDOI
Evaluation of Precision in Optoacoustic Tomography for Preclinical Imaging in Living Subjects
James Joseph,Michal R. Tomaszewski,Isabel Quiros-Gonzalez,Judith Weber,Joanna Brunker,Sarah E. Bohndiek +5 more
TL;DR: Optoacoustic tomography data acquired with the small-animal OT system were highly repeatable and reproducible across subjects and over time, and longitudinal OT studies may be performed with high confidence when the standard operating procedure is followed.
Journal ArticleDOI
ThX – a next-generation probe for the early detection of amyloid aggregates
Lisa-Maria Needham,Judith Weber,Juan A. Varela,James W. B. Fyfe,Dung T. Do,Catherine K. Xu,Luke Tutton,Rachel Cliffe,Benjamin Keenlyside,David Klenerman,Christopher M. Dobson,Christopher A. Hunter,Karin H. Müller,Kevin O'Holleran,Sarah E. Bohndiek,Thomas N. Snaddon,Steven F. Lee +16 more
TL;DR: Thioflavin X, (ThX), a next-generation fluorescent probe which displays superior properties; including a 5-fold increase in brightness and 7-fold increased in binding affinity to amyloidogenic proteins, is designed.
Journal ArticleDOI
An Activatable Cancer-Targeted Hydrogen Peroxide Probe for Photoacoustic and Fluorescence Imaging.
Judith Weber,Laura Bollepalli,Ana M. Belenguer,Marco Di Antonio,Nicola De Mitri,James Joseph,Shankar Balasubramanian,Christopher A. Hunter,Sarah E. Bohndiek +8 more
TL;DR: This work describes the design and synthesis of a targeted, activatable probe for photoacoustic imaging, which is responsive to one of the major and abundant reactive oxygen species, hydrogen peroxide (H2O2), and shows promise for the in vivo visualization of hydrogenperoxide.
Journal Article
Therapeutic effect of m-[131I]- and m-[125I]iodobenzylguanidine on neuroblastoma multicellular tumor spheroids of different sizes.
TL;DR: In this paper, a mathematical model was developed that allows for the calculation of radiation dose rates within small spherical tumors for different distributions of 131I and 125I, and the relationship between tumor size and the therapeutic effects of m -[131I]- and m-[125I]MIBG was studied in vitro using multicellular tumor spheroids of the neuroblastoma cell line SK-N-SH.