J
Judith Weber
Researcher at University of Cambridge
Publications - 12
Citations - 1115
Judith Weber is an academic researcher from University of Cambridge. The author has contributed to research in topics: Molecular imaging & Thioflavin. The author has an hindex of 7, co-authored 11 publications receiving 801 citations.
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Journal ArticleDOI
Distance dependent photoacoustics revealed through DNA nanostructures
James Joseph,Kevin N. Baumann,Philipp Koehler,Tim J. Zuehlsdorff,Daniel J. Cole,Judith Weber,Sarah E. Bohndiek,Silvia Hernández-Ainsa +7 more
TL;DR: PAT of the DNA nanostructures showed distance-dependent photoacoustic signal enhancement and demonstrated the ability of PAT to reveal the FRET process deep within tissue mimicking phantoms.
Journal ArticleDOI
Bifunctional fluorescent probes for detection of amyloid aggregates and reactive oxygen species.
Lisa-Maria Needham,Judith Weber,James W. B. Fyfe,Omaru M. Kabia,Dung T. Do,Ewa Klimont,Yu Zhang,Margarida Rodrigues,Christopher M. Dobson,Sonia Ghandi,Sarah E. Bohndiek,Thomas N. Snaddon,Steven F. Lee +12 more
TL;DR: Four highly sensitive bifunctional fluorescent probes, capable of H2O2 and/or amyloid aggregate detection, are created and results indicate these new probes will be useful to detect and monitor neurodegenerative disease.
Journal ArticleDOI
A Comparative Photophysical Study of Structural Modifications of Thioflavin T-Inspired Fluorophores
Lisa-Maria Needham,Judith Weber,Colin M. Pearson,Dung T. Do,Felix Gorka,Guanpeng Lyu,Sarah E. Bohndiek,Thomas N. Snaddon,Steven F. Lee +8 more
TL;DR: The properties of the derivatives provide new insights into the relationship between chemical structure and function of benzothiazole probes and their abilities to perform super-resolution imaging of α-synuclein fibrils with localisation precisions of ~16 nm.
Posted ContentDOI
ThX - A next-generation probe for the early detection of amyloid aggregates
Lisa-Maria Needham,Judith Weber,Juan A. Varela,James W. B. Fyfe,Dung T. Do,Catherine K. Xu,Benjamin Keenlyside,Rachel Cliffe,David Klenerman,Christopher M. Dobson,Christopher A. Hunter,Sarah E. Bohndiek,Thomas N. Snaddon,Steven F. Lee +13 more
TL;DR: Thioflavin X, (ThX), a next-generation fluorescent probe which displays superior properties and can be used to study unique structural amyloid features both in bulk and on a single-aggregate level, is designed and used as a super-resolution imaging probe in single-molecule localisation microscopy.
Posted ContentDOI
Photoacoustic molecular rulers based on DNA nanostructures
James Joseph,Philipp Koehler,Tim J. Zuehlsdorff,Daniel J. Cole,Kevin N. Baumann,Judith Weber,Sarah E. Bohndiek,Silvia Hernández-Ainsa +7 more
TL;DR: The capability of PAT to probe distance-dependent FRET at centimeter depths is reported and the ability to reveal the FRET process deep within tissue mimicking phantoms is experimentally demonstrated.