J
Juha Saarnio
Researcher at Oulu University Hospital
Publications - 101
Citations - 3717
Juha Saarnio is an academic researcher from Oulu University Hospital. The author has contributed to research in topics: Medicine & Cancer. The author has an hindex of 30, co-authored 84 publications receiving 3300 citations. Previous affiliations of Juha Saarnio include University of Oulu.
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Immunohistochemical study of colorectal tumors for expression of a novel transmembrane carbonic anhydrase, MN/CA IX, with potential value as a marker of cell proliferation
Juha Saarnio,Seppo Parkkila,Anna-Kaisa Parkkila,Kari Haukipuro,Silvia Pastorekova,Jaromir Pastorek,Matti I. Kairaluoma,Tuomo J. Karttunen +7 more
TL;DR: The co-occurrence of MN/CA IX and Ki-67 in the same tumor cells indicates its potential for use as a marker of increased proliferation in the colorectal mucosa, suggesting its involvement in their pathogenesis.
Journal ArticleDOI
Association of HFE protein with transferrin receptor in crypt enterocytes of human duodenum
Abdul Waheed,Seppo Parkkila,Juha Saarnio,Robert E. Fleming,Xiao Yan Zhou,Shunji Tomatsu,Robert S. Britton,Bruce R. Bacon,William S. Sly +8 more
TL;DR: It is proposed that the HFE protein modulates the uptake of transferrin-bound iron from plasma by crypt enterocyte and participates in the mechanism by which the crypt enterocytes sense the level of body iron stores.
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Characterization of CA XIII, a Novel Member of the Carbonic Anhydrase Isozyme Family
Jonna M. Lehtonen,Bairong Shen,Mauno Vihinen,Angela Casini,Andrea Scozzafava,Claudiu T. Supuran,Anna-Kaisa Parkkila,Juha Saarnio,Antti Kivelä,Abdul Waheed,William S. Sly,Seppo Parkkila,Seppo Parkkila +12 more
TL;DR: The predicted amino acid sequence, structural model, distribution, and activity data suggest that CA XIII represents a novel enzyme, which may play important physiological roles in several organs.
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Current Treatment and Outcome of Esophageal Perforations in Adults: Systematic Review and Meta-Analysis of 75 Studies
Fausto Biancari,Vito D'Andrea,Rosalba Paone,Carlo Di Marco,Savino G,Vesa Koivukangas,Juha Saarnio,Ersilia Lucenteforte +7 more
TL;DR: Results of recent studies indicate that mortality after esophageal perforation is high despite any definitive surgical or conservative strategy, and stent-grafting is associated with somewhat lower mortality rates, but studies may be biased by patient selection and limited experience.
Journal ArticleDOI
Immunohistochemistry of Carbonic Anhydrase Isozyme IX (MN/CA IX) in Human Gut Reveals Polarized Expression in the Epithelial Cells with the Highest Proliferative Capacity
Juha Saarnio,Seppo Parkkila,Seppo Parkkila,Anna-Kaisa Parkkila,Anna-Kaisa Parkkila,Abdul Waheed,Matthew C. Casey,Xiao Yan Zhou,Silvia Pastorekova,Jaromir Pastorek,Tuomo J. Karttunen,Kari Haukipuro,Matti I. Kairaluoma,William S. Sly +13 more
TL;DR: In this paper, the authors presented localization of MN/CA IX in human gut and compared its distribution to those of CA I, II, and IV, which are known to be expressed in the intestinal epithelium.