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Andrea Scozzafava
Researcher at University of Florence
Publications - 667
Citations - 39000
Andrea Scozzafava is an academic researcher from University of Florence. The author has contributed to research in topics: Carbonic anhydrase & Enzyme. The author has an hindex of 97, co-authored 667 publications receiving 36499 citations. Previous affiliations of Andrea Scozzafava include University of Siena & University of Milan.
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PatentDOI
Carbonic anhydrase inhibitors
Peter Ebbesen,Claudlu T. Supuran,Andrea Scozzafava,Erik Olai Pettersen,Kaye Williams,L.J. Dubois,Philippe Lambin +6 more
TL;DR: A carbonic anhydrase IX (CA IX) inhibitor is a compound of general formula: R-NH-CX-NH-(CH 2 ) n -Ar-Q-SO 2 -NH 2 or a pharmaceutically acceptable salt, derivative or prodrug thereof.
Journal ArticleDOI
Carbonic Anhydrase Inhibitors
TL;DR: The use of such enzyme inhibitors as antiglaucoma drugs will be discussed in detail, together with the recent developments that led to isozyme-specific and organ-selective inhibitors.
Journal ArticleDOI
Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH.
Eliska Svastova,Alžbeta Hulı́ková,Monika Rafajová,Miriam Zatovicova,Adriana Gibadulinova,Angela Casini,Alessandro Cecchi,Andrea Scozzafava,Claudiu T. Supuran,Jaromir Pastorek,Silvia Pastorekova +10 more
TL;DR: It is shown that hypoxia regulates both expression and activity of CA IX in order to enhance the extracellular acidification, which may have important implications for tumor progression.
Journal ArticleDOI
Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors
Yuanmei Lou,Paul C. McDonald,Arusha Oloumi,Stephen Chia,Christina Ostlund,Ardalan Ahmadi,Alastair H. Kyle,Ulrich auf dem Keller,Samuel Leung,David G. Huntsman,Blaise A. Clarke,Brent W. Sutherland,Dawn Waterhouse,Marcel B. Bally,Calvin D. Roskelley,Christopher M. Overall,Andrew I. Minchinton,Fabio Pacchiano,Fabrizio Carta,Andrea Scozzafava,Nadia Touisni,Jean-Yves Winum,Claudiu T. Supuran,Shoukat Dedhar +23 more
TL;DR: The findings show that CAIX is vital for growth and metastasis of hypoxic breast tumors and is a specific, targetable biomarker for breast cancer metastasis.
Journal ArticleDOI
Anticancer and antiviral sulfonamides.
TL;DR: The review summarizes recent classes of sulfonamides and related sulfonyl derivatives disclosed as effective tumor cell growth inhibitors, or for the treatment of different types of cancer.