R
Raj Bhayadia
Researcher at Martin Luther University of Halle-Wittenberg
Publications - 25
Citations - 476
Raj Bhayadia is an academic researcher from Martin Luther University of Halle-Wittenberg. The author has contributed to research in topics: Myeloid leukemia & Cancer research. The author has an hindex of 7, co-authored 13 publications receiving 284 citations. Previous affiliations of Raj Bhayadia include Hannover Medical School.
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Journal ArticleDOI
Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome.
M Labuhn,Kelly J. Perkins,Sören Matzk,Sören Matzk,Leila N. Varghese,Catherine Garnett,Elli Papaemmanuil,Marlen Metzner,Alison Kennedy,Vyacheslav Amstislavskiy,Thomas Risch,Raj Bhayadia,David Samulowski,David Cruz Hernandez,Bilyana Stoilova,Valentina Iotchkova,Udo Oppermann,C Scheer,Kenichi Yoshida,Adrian Schwarzer,Jeffrey W. Taub,John D. Crispino,Mitchell J. Weiss,Yasuhide Hayashi,Takashi Taga,Etsuro Ito,Seishi Ogawa,Seishi Ogawa,Dirk Reinhardt,Marie-Laure Yaspo,Peter J. Campbell,Irene Roberts,Stefan N. Constantinescu,Paresh Vyas,Dirk Heckl,Dirk Heckl,Jan-Henning Klusmann +36 more
TL;DR: This work combined exome and targeted resequencing of 111 TAM and 141 ML-DS samples with functional analyses to define mechanisms of leukemic transformation, and identified a recurrent and oncogenic hotspot gain-of-function mutation in myeloid cytokine receptor CSF2RB.
Journal ArticleDOI
Senescence-Induced Oxidative Stress Causes Endothelial Dysfunction
TL;DR: It is shown that both, aging and senescence induced by telomere shortening, cause endothelial dysfunction that can be restored by antioxidants, indicating a role for oxidative stress.
Journal ArticleDOI
Vascular importance of the miR-212/132 cluster
Regalla Kumarswamy,Ingo Volkmann,Julia Beermann,L C Napp,Olga Jabs,Raj Bhayadia,Anette Melk,Ahmet Ucar,Kamal Chowdhury,Johan M. Lorenzen,Shashi Kumar Gupta,Sandor Batkai,Thomas Thum +12 more
TL;DR: The authors' results identify a novel miRNA-cross-talk involving miR-30a-3p andmiR-212, which led to suppression of important endothelial genes such as GAB1 and SIRT1 finally culminating in impaired endothelial function; and microRNAs may have different biological roles despite having the same seed sequence.
Journal ArticleDOI
Neutral pH and low–glucose degradation product dialysis fluids induce major early alterations of the peritoneal membrane in children on peritoneal dialysis
Betti Schaefer,Maria Bartosova,Stephan Macher-Goeppinger,Peter Sallay,Péter Vörös,Bruno Ranchin,Karel Vondrak,Gema Ariceta,Ariane Zaloszyc,Aysun Karabay Bayazit,Uwe Querfeld,Rimante Cerkauskiene,Sara Testa,Christina Taylan,Johan VandeWalle,Yok Chin Yap,Rafael T. Krmar,Rainer Büscher,Anne K Mühlig,Dorota Drozdz,Salim Caliskan,Felix Lasitschka,Sahar Fathallah-Shaykh,Enrico Verrina,Günter Klaus,Klaus Arbeiter,Raj Bhayadia,Anette Melk,Philipp Romero,Bradley A. Warady,Franz Schaefer,Akos Ujszaszi,Claus Peter Schmitt +32 more
TL;DR: In children on peritoneal dialysis neutral pH dialysates containing low-glucose degradation products induce early peritoneAL inflammation, fibroblast activation, epithelial-mesenchymal transition and marked angiogenesis, which determines the PD membrane transport function.
Journal ArticleDOI
Endogenous Tumor Suppressor microRNA-193b: Therapeutic and Prognostic Value in Acute Myeloid Leukemia
Raj Bhayadia,Kathrin Krowiorz,Nadine Haetscher,Razan Jammal,Stephan Emmrich,Askar Obulkasim,Jan Fiedler,Adrian Schwarzer,Arefeh Rouhi,Michael Heuser,Susanne Wingert,Sabrina Bothur,Konstanze Döhner,Tobias Mätzig,Michelle Ng,Dirk Reinhardt,Hartmut Döhner,C. Michel Zwaan,Marry M. Van den Heuvel Eibrink,Dirk Heckl,Maarten Fornerod,Thomas Thum,R. Keith Humphries,Michael A. Rieger,Florian Kuchenbauer,Jan-Henning Klusmann +25 more
TL;DR: The tumor-suppressive function of miR-193b would assure high antileukemic efficacy by blocking the entire MAPK signaling cascade while preventing the emergence of resistance mechanisms.