J
Julia Okrut
Researcher at University of California, San Francisco
Publications - 3
Citations - 884
Julia Okrut is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Phosphorylation & Cell signaling. The author has an hindex of 2, co-authored 3 publications receiving 590 citations. Previous affiliations of Julia Okrut include Howard Hughes Medical Institute.
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Journal ArticleDOI
Phase separation of signaling molecules promotes T cell receptor signal transduction
Xiaolei Su,Xiaolei Su,Jonathon A. Ditlev,Jonathon A. Ditlev,Enfu Hui,Enfu Hui,Wenmin Xing,Wenmin Xing,Sudeep Banjade,Sudeep Banjade,Julia Okrut,Julia Okrut,David S. King,Jack Taunton,Jack Taunton,Michael K. Rosen,Michael K. Rosen,Ronald D. Vale,Ronald D. Vale +18 more
TL;DR: It is demonstrated that protein phase separation can create a distinct physical and biochemical compartment that facilitates signaling and promote signaling outputs both in vitro and in human Jurkat T cells.
Journal ArticleDOI
Allosteric N-WASP activation by an inter-SH3 domain linker in Nck
TL;DR: The results suggest that animals, like pathogenic bacteria, have evolved peptide motifs that allosterically activate N-WASP, leading to localized actin nucleation on cellular membranes.
Proceedings ArticleDOI
Abstract A087: Phase separation of signaling molecules promotes T cell receptor signal transduction
Xiaolei Su,Jon Ditlev,Enfu Hui,Sudeep Banjade,Julia Okrut,Jack Taunton,Mike Rosen,Ronald D. Vale +7 more
TL;DR: It is established that microclusters create unique physical and biochemical environments that promote reactions in TCR signaling, and the principles revealed here likely apply to other systems that exploit phase separation to regulate biochemical reactions on membranes, in the cytoplasm, or the nucleus.