J
Jonathon A. Ditlev
Researcher at Howard Hughes Medical Institute
Publications - 31
Citations - 2449
Jonathon A. Ditlev is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Chemistry & Transmembrane protein. The author has an hindex of 13, co-authored 26 publications receiving 1599 citations. Previous affiliations of Jonathon A. Ditlev include University of Texas Southwestern Medical Center & University of Toronto.
Papers
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Journal ArticleDOI
Phase separation of signaling molecules promotes T cell receptor signal transduction
Xiaolei Su,Xiaolei Su,Jonathon A. Ditlev,Jonathon A. Ditlev,Enfu Hui,Enfu Hui,Wenmin Xing,Wenmin Xing,Sudeep Banjade,Sudeep Banjade,Julia Okrut,Julia Okrut,David S. King,Jack Taunton,Jack Taunton,Michael K. Rosen,Michael K. Rosen,Ronald D. Vale,Ronald D. Vale +18 more
TL;DR: It is demonstrated that protein phase separation can create a distinct physical and biochemical compartment that facilitates signaling and promote signaling outputs both in vitro and in human Jurkat T cells.
Journal ArticleDOI
Stoichiometry controls activity of phase-separated clusters of actin signaling proteins
Lindsay B. Case,Lindsay B. Case,Xu Zhang,Jonathon A. Ditlev,Jonathon A. Ditlev,Michael K. Rosen,Michael K. Rosen +6 more
TL;DR: Two papers show how biomolecular condensates function in actin assembly or in a Ras signaling pathway, and show that the dwell time is dependent on cluster stoichiometry, so that stoichiometric of regulatory proteins can control actinAssembly.
Journal ArticleDOI
Who's In and Who's Out-Compositional Control of Biomolecular Condensates.
TL;DR: This review discusses current models and data regarding the control of condensate composition, and describes the current understanding of the composition of representative condensates including PML nuclear bodies, P-bodies, stress granules, the nucleolus, and two-dimensional membrane localized LAT and nephrin clusters.
Journal ArticleDOI
A Molecular Classification of Papillary Renal Cell Carcinoma
Ximing J. Yang,Min-Han Tan,Min-Han Tan,Hyung L. Kim,Jonathon A. Ditlev,Mark Betten,Carolina E. Png,Eric J. Kort,Kunihiko Futami,Kyle A. Furge,Masayuki Takahashi,Masayuki Takahashi,Hiro-omi Kanayama,Puay Hoon Tan,Bin Sing Teh,Chunyan Luan,Kim L. Wang,Michael R. Pins,Maria Tretiakova,John Anema,Richard J. Kahnoski,Theresa L. Nicol,Walter M. Stadler,Nicholas G. Vogelzang,Robert J. Amato,David Seligson,Robert A. Figlin,Arie S. Belldegrun,Craig G. Rogers,Bin Tean Teh +29 more
TL;DR: Two molecular subclasses of PRCC are reported, which are biologically and clinically distinct and may be readily distinguished in a clinical setting and identified two highly distinct molecular PRCC subclasses with morphologic correlation.
Journal ArticleDOI
Regulation of Transmembrane Signaling by Phase Separation.
TL;DR: It is suggested that these clusters share properties of systems that undergo liquid-liquid phase separation and could be investigated in this light.