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Xiaolei Su
Researcher at Yale University
Publications - 30
Citations - 2909
Xiaolei Su is an academic researcher from Yale University. The author has contributed to research in topics: T-cell receptor & Signal transduction. The author has an hindex of 10, co-authored 24 publications receiving 1822 citations. Previous affiliations of Xiaolei Su include Marine Biological Laboratory & Howard Hughes Medical Institute.
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Journal ArticleDOI
T cell costimulatory receptor CD28 is a primary target for PD-1-mediated inhibition.
Enfu Hui,Jeanne Cheung,Jing Zhu,Xiaolei Su,Marcus J. Taylor,Heidi J.A. Wallweber,Dibyendu Kumar Sasmal,Jun Huang,Jeong M. Kim,Ira Mellman,Ronald D. Vale +10 more
TL;DR: It is shown that the co-receptor CD28 is strongly preferred over the TCR as a target for dephosphorylation by PD-1–recruited Shp2 phosphatase, suggesting that costimulatory pathways play key roles in regulating effector T cell function and responses to anti-PD-L1/PD-1 therapy.
Journal ArticleDOI
Phase separation of signaling molecules promotes T cell receptor signal transduction
Xiaolei Su,Xiaolei Su,Jonathon A. Ditlev,Jonathon A. Ditlev,Enfu Hui,Enfu Hui,Wenmin Xing,Wenmin Xing,Sudeep Banjade,Sudeep Banjade,Julia Okrut,Julia Okrut,David S. King,Jack Taunton,Jack Taunton,Michael K. Rosen,Michael K. Rosen,Ronald D. Vale,Ronald D. Vale +18 more
TL;DR: It is demonstrated that protein phase separation can create a distinct physical and biochemical compartment that facilitates signaling and promote signaling outputs both in vitro and in human Jurkat T cells.
Posted ContentDOI
T cell co-stimulatory receptor CD28 is a primary target for PD-1-mediated inhibition
Enfu Hui,Jeanne Cheung,Jing Zhu,Xiaolei Su,Marcus J. Taylor,Heidi J.A. Wallweber,Dibyendu Kumar Sasmal,Jun Huang,Jeong M. Kim,Ira Mellman,Ronald D. Vale +10 more
TL;DR: It is demonstrated that the coreceptor CD28 is strongly preferred over the TCR as a target for dephosphorylation by PD-1- recruited Shp2 phosphatase, suggesting that costimulatory pathways may play unexpected roles in regulating effector T cell function and therapeutic responses to anti-PD-L1/PD-1.
Journal ArticleDOI
Mechanisms Underlying the Dual-Mode Regulation of Microtubule Dynamics by Kip3/Kinesin-8
Xiaolei Su,Weihong Qiu,Mohan L. Gupta,José B. Pereira-Leal,Samara L. Reck-Peterson,David Pellman +5 more
TL;DR: A concentration-dependent model for the coordination of the destabilizing and stabilizing activities of Kip3 is proposed and its relevance to cellular microtubule organization is discussed.
Journal ArticleDOI
Microtubule-sliding activity of a kinesin-8 promotes spindle assembly and spindle-length control.
Xiaolei Su,Hugo Arellano-Santoyo,Hugo Arellano-Santoyo,Didier Portran,Jérémie Gaillard,Marylin Vantard,Manuel Thery,David Pellman,David Pellman +8 more
TL;DR: An antiparallel microtubule-sliding activity of the budding yeast kinesin-8, Kip3 is reported, which promotes bipolar spindle assembly and the maintenance of genome stability and proposes a slide–disassemble model where the sliding and destabilizing activity of Kip2 balance during pre-anaphase.