J
Julia Steitz
Researcher at RWTH Aachen University
Publications - 48
Citations - 1877
Julia Steitz is an academic researcher from RWTH Aachen University. The author has contributed to research in topics: Antigen & Immune system. The author has an hindex of 21, co-authored 42 publications receiving 1715 citations. Previous affiliations of Julia Steitz include University of Mainz & University of Bonn.
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Journal Article
Depletion of CD25(+) CD4(+) T cells and treatment with tyrosinase-related protein 2-transduced dendritic cells enhance the interferon alpha-induced, CD8(+) T-cell-dependent immune defense of B16 melanoma.
TL;DR: Evidence that CD4(+) T cells down-regulate the IFN alpha-induced tumor immune defense is provided, supporting the development of novel strategies for the immunotherapy of melanoma using IFNalpha in combination with elimination of regulatory T cells or antigen-specific immunization.
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Immune Cell–Poor Melanomas Benefit from PD-1 Blockade after Targeted Type I IFN Activation
Tobias Bald,Jennifer Landsberg,Dorys Lopez-Ramos,Marcel Renn,Nicole Glodde,Philipp Jansen,Evelyn Gaffal,Julia Steitz,Rene Tolba,Ulrich Kalinke,Andreas Limmer,Göran Jönsson,Michael Hölzel,Thomas Tüting +13 more
TL;DR: Using a genetically engineered mouse melanoma model, it is demonstrated that targeted activation of the type I IFN system with immunostimulatory RNA in combination with blockade of immune-inhibitory receptors is a rational strategy to expose immune cell-poor tumors to cellular immune surveillance.
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Systemic application of CpG-rich DNA suppresses adaptive T cell immunity via induction of IDO
Gerhard Wingender,Natalio Garbi,Beatrix Schumak,Frank Jüngerkes,Elmar Endl,Dagmar von Bubnoff,Julia Steitz,Jörg Striegler,G. Moldenhauer,Thomas Tüting,Antje Heit,Katharina M. Huster,Osamu Takikawa,Shizuo Akira,Dirk H. Busch,Hermann Wagner,Günter J. Hämmerling,Percy A. Knolle,Andreas Limmer +18 more
TL;DR: The present study shows that for the use of CpG‐ODN as an adjuvant in vaccines, the route of application is crucial and needs to be considered and indicates that down‐modulation of immune responses by C pG‐ ODN may be possible in certain pathological conditions.
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Sonoporation enhances liposome accumulation and penetration in tumors with low EPR
Benjamin Theek,Maike Baues,Tarun Ojha,Diana Möckel,Seena Koyadan Veettil,Julia Steitz,Louis van Bloois,Gert Storm,Fabian Kiessling,Twan Lammers,Twan Lammers,Twan Lammers +11 more
TL;DR: In treated tumors, liposome concentrations were up to twice as high as in untreated tumors, and sonoporation enhanced the ability of liposomes to extravasate out of the blood vessels into the tumor interstitium.
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Genetic immunization of mice with human tyrosinase-related protein 2: implications for the immunotherapy of melanoma.
TL;DR: Genetic immunization of mice with human TRP2 resulted in coat depigmentation as a sign of autoimmune‐mediated destruction of melanocytes and provided significant protection against metastatic growth of B16 melanoma.