Julia Tsou Tsan

TL;DR: This BRCA1–associated RING domain (BARD1) protein contains an N–terminal RING motif, three tandem ankyrin repeats, and a C-terminal sequence with significant homology to the phylogenetically conserved BRCT domains that lie near the C terminus of BRCa1.

TL;DR: The genomic structure of BARD1 is determined and a mutational analysis of ovarian tumors, breast tumors and 60 uterine tumors suggests an occasional role for Bard1 mutations in the development of sporadic and hereditary tumors.

TL;DR: The identification of TAL2 is reported, a distinct gene that was isolated on the basis of its sequence homology with TAL1, a discrete subgroup of helix-loop-helix proteins that can potentially contribute to the development of T-ALL.

TL;DR: In this article, a binding site selection procedure was used to evaluate the DNA recognition properties of TAL1 polypeptides, and it was shown that the TAL-1 heterodimers preferentially recognize a subset of E-box elements that can be represented by the consensus sequence AACAGATGGT.

TL;DR: TAL1 can regulate the transcription of an artificial reporter gene that contains binding sites for bHLH heterodimers involving TAL1, and can potentially regulate transcription in either a positive or negative fashion.