J
J. Michael Mathis
Researcher at Louisiana State University
Publications - 83
Citations - 3038
J. Michael Mathis is an academic researcher from Louisiana State University. The author has contributed to research in topics: Cancer & Genetic enhancement. The author has an hindex of 29, co-authored 83 publications receiving 2833 citations. Previous affiliations of J. Michael Mathis include Louisiana State University in Shreveport & LSU Health Sciences Center Shreveport.
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Journal ArticleDOI
Placebo-controlled trial of indole-3-carbinol in the treatment of CIN
Maria C. Bell,Peg Crowley-Nowick,H. Leon Bradlow,Daniel W. Sepkovic,Delf Schmidt-Grimminger,Patti Howell,E.J. Mayeaux,Angela Tucker,Elba A. Turbat-Herrera,J. Michael Mathis +9 more
TL;DR: There was a statistically significant regression of CIN in patients treated with I-3-C orally compared with placebo, and the 2/16 alpha-hydroxyestrone ratio changed in a dose-dependent fashion.
Journal ArticleDOI
Mesenchymal stem cells as a vehicle for targeted delivery of CRAds to lung metastases of breast carcinoma.
Mariam A. Stoff-Khalili,Angel A. Rivera,J. Michael Mathis,N. Sanjib Banerjee,Amanda S Moon,Alexandra P. Hess,Rodney P. Rocconi,T. Michael Numnum,Maaike Everts,Louise T. Chow,Joanne T. Douglas,Gene P. Siegal,Zeng B. Zhu,Hans Georg Bender,Peter Dall,Alexander Stoff,Larissa Pereboeva,David T. Curiel +17 more
TL;DR: Intravenous injection of CRAd loaded hMSCs into mice with established MDA-MB-231 pulmonary metastatic disease homed to the tumor site led to extended mouse survival compared to mice treated with CRAd alone and may be an effective platform for the targeted delivery of CR adenoviruses to distant cancer sites such as metastatic breast cancer.
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Mutations in the BRCA1-associated RING domain (BARD1) gene in primary breast, ovarian and uterine cancers
To Hoa Thai,Fenghe Du,Julia Tsou Tsan,Ying Jin,Anne Phung,Monique A. Spillman,Hillary Massa,Carolyn Y. Muller,Raheela Ashfaq,J. Michael Mathis,David Miller,Barbara J. Trask,Richard Baer,Anne M. Bowcock +13 more
TL;DR: The genomic structure of BARD1 is determined and a mutational analysis of ovarian tumors, breast tumors and 60 uterine tumors suggests an occasional role for Bard1 mutations in the development of sporadic and hereditary tumors.
Journal ArticleDOI
Angiotensin II and potassium regulate human CYP11B2 transcription through common cis-elements.
TL;DR: Deletion, mutation, and deoxyribonuclease I footprinting analyses of the CYP11B2 5'-flanking region identified two distinct elements at positions -71/-64 (TGACGTGA) and -129/-114 (CTCCAGCCTTGACCTT) that were both required for full basal reporter gene activity and for maximal induction by either cAMP or calcium-signaling pathways.
Journal ArticleDOI
Role of the endothelium in inflammatory bowel diseases
Walter E. Cromer,J. Michael Mathis,Daniel N. Granger,Ganta Vijay Chaitanya,J. Steven Alexander +4 more
TL;DR: This review examines the roles of the endothelium in the initiation and propagation of IBD pathology and distinctive features of the intestinal endothelia contributing to these conditions.