W
Woodring E. Wright
Researcher at University of Texas Southwestern Medical Center
Publications - 356
Citations - 55880
Woodring E. Wright is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Telomerase & Telomere. The author has an hindex of 109, co-authored 356 publications receiving 53087 citations. Previous affiliations of Woodring E. Wright include Harvard University & Blackburn College.
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Journal ArticleDOI
Specific association of human telomerase activity with immortal cells and cancer
Nam Woo Kim,Mieczyslaw A. Piatyszek,Karen R. Prowse,Calvin B. Harley,Michael D. West,Peter L. C. Ho,Gina M. Coviello,Woodring E. Wright,Scott L. Weinrich,Jerry W. Shay +9 more
TL;DR: A highly sensitive assay for measuring telomerase activity was developed in this paper, which showed that telomerases appear to be stringently repressed in normal human somatic tissues but reactivated in cancer, where immortal cells are likely required to maintain tumor growth.
Journal ArticleDOI
Extension of life-span by introduction of telomerase into normal human cells
Andrea G. Bodnar,Michel M. Ouellette,Maria Frolkis,Shawn E. Holt,Choy-Pik Chiu,Gregg B. Morin,Calvin B. Harley,Jerry W. Shay,Serge Lichtsteiner,Woodring E. Wright +9 more
TL;DR: In this article, two telomerase-negative normal human cell types, retinal pigment epithelial cells and foreskin fibroblasts, were transfected with vectors encoding the human telomere catalytic subunit.
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Telomerase activity in human germline and embryonic tissues and cells
TL;DR: Elucidation of the regulatory pathways involved in the repression of telomerase activity during development may lead to the ability to manipulate telomere levels and explore the consequences both for cellular aging and for the survival of cancer cells.
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Myogenin, a Factor Regulating Myogenesis, Has a Domain Homologous to MyoD
TL;DR: The isolation, sequence, and initial characterization of the cDNA for the muscle-specific regulatory factor skeletal myogenin are described, and together with myd may constitute a set of factors that interact to regulate the determination and differentiation of muscle cells.
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Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT
Scott L. Weinrich,Ron Pruzan,Libin Ma,Michel M. Ouellette,Valeric M. Tesmer,Shawn E. Holt,Andrea G. Bodnar,Serge Lichtsteiner,Nam Woo Kim,James B. Trager,Rebecca D. Taylor,Ruben Carlos,William H. Andrews,Woodring E. Wright,Jerry W. Shay,Calvin B. Harley,Gregg B. Morin +16 more
TL;DR: In vitro transcription and translation of hTRT when co-synthesized or mixed with hTR reconstitutes telomerase activity that exhibits enzymatic properties like those of the native enzyme.