J
Julia Wirmer-Bartoschek
Publications - 1
Citations - 47
Julia Wirmer-Bartoschek is an academic researcher. The author has contributed to research in topics: Paromomycin. The author has an hindex of 1, co-authored 1 publications receiving 44 citations.
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Structure-Based Design, Synthesis, and A-Site rRNA Cocrystal Complexes of Functionally Novel Aminoglycoside Antibiotics: C2'' Ether Analogues of Paromomycin
Stephen Hanessian,Janek Szychowski,Susanta Adhikari,Guillermo Vasquez,Pachamuthu Kandasamy,Eric E. Swayze,Michael T. Migawa,Ray Ranken,Boris François,Julia Wirmer-Bartoschek,Jiro Kondo,Eric Westhof +11 more
TL;DR: In this paper, a series of 2 O-substituted ether analogues of paromomycin were prepared based on new site-selective functionalizations, and X-ray cocrystal complexes of several such analogues revealed a new mode of binding in the A-site rRNA, whereby rings I and II adopted the familiar orientation and position previously observed with paromycin, but rings III and IV were oriented differently.