J
Julia Zeitlinger
Researcher at Stowers Institute for Medical Research
Publications - 64
Citations - 15872
Julia Zeitlinger is an academic researcher from Stowers Institute for Medical Research. The author has contributed to research in topics: Enhancer & RNA polymerase II. The author has an hindex of 32, co-authored 58 publications receiving 14655 citations. Previous affiliations of Julia Zeitlinger include Massachusetts Institute of Technology & University of Kansas.
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Journal ArticleDOI
Base-resolution models of transcription-factor binding reveal soft motif syntax.
Žiga Avsec,Žiga Avsec,Melanie Weilert,Avanti Shrikumar,Sabrina Krueger,Amr Alexandari,Khyati Dalal,Khyati Dalal,Robin Fropf,Charles McAnany,Julien Gagneur,Anshul Kundaje,Julia Zeitlinger,Julia Zeitlinger +13 more
TL;DR: BPNet as discussed by the authors uses DNA sequence to predict base-resolution chromatin immunoprecipitation (ChIP)-nexus binding profiles of pluripotency transcription factor (TF) binding motifs.
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ChIP-nexus enables improved detection of in vivo transcription factor binding footprints
TL;DR: It is shown that Max frequently interacts with DNA sequences next to its motif, and that this binding pattern correlates with local DNA-sequence features such as DNA shape, which will be broadly applicable to the study of in vivo transcription factor binding specificity and its relationship to cis-regulatory changes in humans and model organisms.
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Paused RNA polymerase II inhibits new transcriptional initiation
TL;DR: Using the recently developed ChIP-nexus method, it is found that Pol II pausing inhibits new initiation and proposed that paused Pol II helps prevent new initiation between transcription bursts, which may reduce noise.
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Suppression of m6A reader Ythdf2 promotes hematopoietic stem cell expansion
Zhenrui Li,Pengxu Qian,Pengxu Qian,Wanqing Shao,Hailing Shi,Xi C. He,Madelaine Gogol,Zulin Yu,Yongfu Wang,Meijie Qi,Yunfei Zhu,John M. Perry,Kai Zhang,Fang Tao,Kun Zhou,Kun Zhou,Deqing Hu,Deqing Hu,Yingli Han,Chongbei Zhao,Richard Alexander,Hanzhang Xu,Shiyuan Chen,Allison Peak,Kathyrn Hall,Michael Peterson,Anoja Perera,Jeffrey S. Haug,Tari Parmely,Hua Li,Bin Shen,Julia Zeitlinger,Chuan He,Chuan He,Linheng Li,Linheng Li +35 more
TL;DR: This study provides the first demonstration of the function of YTHDF2 in adult stem cell maintenance and identifies its important role in regulating HSC ex vivo expansion by regulating the stability of multiple mRNAs critical for HSC self-renewal, thus identifying potential for future clinical applications.
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Thorax closure in Drosophila: involvement of Fos and the JNK pathway
Julia Zeitlinger,Dirk Bohmann +1 more
TL;DR: The hypothesis that the mechanism controlling dorsal closure has been co-opted for thorax closure in the evolution of insect metamorphosis is supported and may represent a more widely used functional module for tissue closure in other species as well.