J
Julia Zeitlinger
Researcher at Stowers Institute for Medical Research
Publications - 64
Citations - 15872
Julia Zeitlinger is an academic researcher from Stowers Institute for Medical Research. The author has contributed to research in topics: Enhancer & RNA polymerase II. The author has an hindex of 32, co-authored 58 publications receiving 14655 citations. Previous affiliations of Julia Zeitlinger include Massachusetts Institute of Technology & University of Kansas.
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Journal ArticleDOI
Hippo Reprograms the Transcriptional Response to Ras Signaling
Justine Pascual,Jelle Jacobs,Leticia Sansores-Garcia,Malini Natarajan,Julia Zeitlinger,Julia Zeitlinger,Stein Aerts,Georg Halder,Fisun Hamaratoglu +8 more
TL;DR: Using ChIP-nexus, Hippo signaling is found to keep Ras targets in check by directly regulating the expression of two key downstream transcription factors of Ras signaling: the ETS-domain transcription factor Pointed and the repressor Capicua.
Journal ArticleDOI
HOXA1 and TALE proteins display cross-regulatory interactions and form a combinatorial binding code on HOXA1 targets.
Bony De Kumar,Hugo J. Parker,Ariel Paulson,Mark E. Parrish,Irina Pushel,Narendra Pratap Singh,Ying Zhang,Brian D. Slaughter,Jay R. Unruh,Laurence Florens,Julia Zeitlinger,Robb Krumlauf,Robb Krumlauf +12 more
TL;DR: Extensive auto- and cross-regulatory interactions among the Hoxa1 and TALE genes are discovered, indicating that the specificity of HOXA1 during development may be regulated though a complex cross-Regulatory network of HOxA1 andTALE proteins.
Journal ArticleDOI
A Role for FACT in RNA Polymerase II Promoter-Proximal Pausing.
Theophilus T. Tettey,Theophilus T. Tettey,Xin Gao,Wanqing Shao,Hua Li,Benjamin A. Story,Alex D. Chitsazan,Robert L. Glaser,Zach H. Goode,Christopher Seidel,Ronald C. Conaway,Ronald C. Conaway,Julia Zeitlinger,Julia Zeitlinger,Marco Blanchette,Joan W. Conaway,Joan W. Conaway +16 more
TL;DR: Evidence is presented that loss of FACT has a dramatic impact on Pol II elongation-coupled processes including histone H3 lysine 4 (H3K4) and H3K36 methylation, consistent with a role for FACT in coordinating histone modification and chromatin architecture during Pol II transcription.
Posted ContentDOI
Deep learning at base-resolution reveals motif syntax of the cis-regulatory code
Žiga Avsec,Melanie Weilert,Avanti Shrikumar,Amr Alexandari,Sabrina Krueger,Khyati Dalal,Khyati Dalal,Robin Fropf,Charles McAnany,Julien Gagneur,Anshul Kundaje,Julia Zeitlinger,Julia Zeitlinger +12 more
TL;DR: A deep learning model is trained that uses DNA sequence to predict base-resolution binding profiles of four pluripotency transcription factors Oct4, Sox2, Nanog, and Klf4 and finds that instances of strict motif spacing are largely due to retrotransposons, but that soft motif syntax influences motif interactions at protein and nucleosome range.
Journal ArticleDOI
Capicua controls Toll/IL-1 signaling targets independently of RTK regulation.
Aikaterini Papagianni,Marta Forés,Wanqing Shao,Shuonan He,Nina Koenecke,María José Andreu,Núria Samper,Ze'ev Paroush,Sergio González-Crespo,Julia Zeitlinger,Julia Zeitlinger,Gerardo Jiménez +11 more
TL;DR: It is shown that Cic represses Toll/IL-1 signaling targets in Drosophila embryos independently of RTK control, revealing a mode of Cic regulation unrelated to the well-established RTK/Cic depression axis and implicate cooperative binding in conjunction with low-affinity binding sites as an important mechanism of enhancer regulation.