J
Julian I. Borissoff
Researcher at Maastricht University
Publications - 18
Citations - 2030
Julian I. Borissoff is an academic researcher from Maastricht University. The author has contributed to research in topics: Thrombin & Neutrophil extracellular traps. The author has an hindex of 12, co-authored 17 publications receiving 1753 citations. Previous affiliations of Julian I. Borissoff include Harvard University & Boston Children's Hospital.
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Journal ArticleDOI
The Hemostatic System as a Modulator of Atherosclerosis
TL;DR: Experimental data indicate that platelets and the coagulation system are important determinants of both atherogenesis and ath inplex diseases, including atherosclerosis.
Journal ArticleDOI
Elevated levels of circulating DNA and chromatin are independently associated with severe coronary atherosclerosis and a prothrombotic state.
Julian I. Borissoff,Ivo A. Joosen,Mathijs O. Versteylen,Alexander Brill,Alexander Brill,Tobias A. Fuchs,Tobias A. Fuchs,Alexander Savchenko,Alexander Savchenko,Maureen Gallant,Kimberly Martinod,Kimberly Martinod,Hugo ten Cate,Leonard Hofstra,Harry J.G.M. Crijns,Denisa D. Wagner,Denisa D. Wagner,Bas L.J.H. Kietselaer +17 more
TL;DR: Evidence is provided demonstrating that markers of cell death and neutrophil extracellular trap formation are independently associated with coronary artery disease, prothrombotic state, and occurrence of adverse cardiac events.
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Neutrophil extracellular traps form predominantly during the organizing stage of human venous thromboembolism development
Alexander Savchenko,Alexander Savchenko,Kim Martinod,Kim Martinod,Michael A. Seidman,Siu Ling Wong,Siu Ling Wong,Julian I. Borissoff,Julian I. Borissoff,Gregory Piazza,Peter Libby,Samuel Z. Goldhaber,Richard N. Mitchell,Denisa D. Wagner,Denisa D. Wagner +14 more
TL;DR: A growing health problem, venous thromboembolism (VTE), including pulmonary embolism and deep vein thrombosis (DVT), requires refined diagnostic and therapeutic approaches and neutrophil extracellular traps as an important scaffold supporting thrombus stability is recognized.
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Is thrombin a key player in the ‘coagulation-atherogenesis’ maze?
TL;DR: There is mounting evidence that thrombin acts as a powerful modulator of many processes like regulation of vascular tone, permeability, migration and proliferation of VSMC, recruitment of monocytes into the atherosclerotic lesions, induction of diverse pro-inflammatory markers, and all of these are related to the progression of cardiovascular disease.
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VWF-mediated leukocyte recruitment with chromatin decondensation by PAD4 increases myocardial ischemia/reperfusion injury in mice
Alexander Savchenko,Julian I. Borissoff,Kimberly Martinod,Kimberly Martinod,Simon F. De Meyer,Maureen Gallant,Luise Erpenbeck,Alexander Brill,Yanming Wang,Denisa D. Wagner +9 more
TL;DR: It is demonstrated that extracellular chromatin released through NETosis exacerbates MI/R injury, and targeting both VWF-mediated leukocyte recruitment and chromatin removal may be a new therapeutic strategy to reduce ischemia-related cardiac damage.