Julian Leff

TL;DR: It is suggested that even after short-term treatment, typical and atypical antipsychotics may affect brain structure differently, as there were no differences in duration of illness, total symptoms scores, and length of treatment among the groups.

TL;DR: It is concluded that neurological soft signs are associated with regional grey matter volume changes and that they may represent a clinical sign of the perturbed cortical-subcortical connectivity that putatively underlies psychotic disorders.

TL;DR: Temporal gray matter reductions are more marked in patients with a long DUP, which could reflect a progressive pathological process that is active prior to treatment and could be associated with a more insidious onset of illness and a later presentation to services.

TL;DR: Reduced general neuropsychological function was linked to poor symptom relabelling ability and the cingulate gyrus (as part of a midline cortical system) along with right hemisphere regions may be involved in illness and symptom self-appraisal in first-onset psychosis.

TL;DR: It is suggested that these cortical brain structural changes represent a common neuroanatomical substrate of NSS, across healthy individuals and patients with psychosis.