Juliana Bender Hoppe

TL;DR: The findings demonstrate that administration of curcumin was effective in preventing behavioral impairments, neuroinflammation, tau hyperphosphorylation as well as cell signaling disturbances triggered by Aβ in vivo, and suggest thatCur-LNC in a dose 20-fold lower presented similar neuroprotective results compared to the effective dose of free curcuming.

TL;DR: Trans-Resveratrol-loaded lipid-core nanocapsules increased the concentration of trans-resver atrol in the brain tissue and Gastrointestinal safety was improved and may be used as an alternative potential therapeutic for several diseases including Alzheimer's disease.

TL;DR: The results clearly show that by using lipid-core nanocapsules, resveratrol was able to rescue the deleterious effects of Aβ1-42 while treatment with RSV presented only partial beneficial effects.

TL;DR: Comparing two commonly used Aβ peptides on an in-vitro model of Aβ toxicity provides strong evidence that Aβ1-42 and the Aβ25-35 peptides induce neural injury in a similar pattern and that A β25- 35 is a convenient tool for the investigation of neurotoxic mechanisms involved in AD.

TL;DR: It is speculated that melatonin may provide an effective therapeutic strategy for AD, by attenuating Aβ‐induced phosphorylation of tau protein, and preventing GSK‐3β activation and neuroinflammation.