R
Rudimar Luiz Frozza
Researcher at Oswaldo Cruz Foundation
Publications - 45
Citations - 3812
Rudimar Luiz Frozza is an academic researcher from Oswaldo Cruz Foundation. The author has contributed to research in topics: Neuroprotection & Resveratrol. The author has an hindex of 25, co-authored 45 publications receiving 2524 citations. Previous affiliations of Rudimar Luiz Frozza include Universidade Federal do Rio Grande do Sul & Federal University of Rio de Janeiro.
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Journal ArticleDOI
The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication
TL;DR: How the development of future treatments for central nervous system (CNS) disorders can take advantage of the intimate and mutual interactions of the gut microbiota with the brain by exploring the role of SCFAs in the regulation of neuro-immunoendocrine function is highlighted.
Journal ArticleDOI
Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's models
Mychael V. Lourenco,Mychael V. Lourenco,Rudimar Luiz Frozza,Rudimar Luiz Frozza,Guilherme B. L. de Freitas,Guilherme B. L. de Freitas,Hong Zhang,Grasielle C. Kincheski,Felipe C. Ribeiro,Rafaella Araujo Gonçalves,Julia R. Clarke,Danielle Beckman,Agnieszka Staniszewski,Hanna Berman,Lorena A. Guerra,Leticia Forny-Germano,Shelby E. Meier,Donna M. Wilcock,Jorge Marcondes de Souza,Soniza Vieira Alves-Leon,Vania F. Prado,Marco A. M. Prado,Jose F. Abisambra,Fernanda Tovar-Moll,Paulo Mattos,Ottavio Arancio,Sergio T. Ferreira,Fernanda G. De Felice,Fernanda G. De Felice +28 more
TL;DR: FNDC5/irisin is placed as a novel agent capable of opposing synapse failure and memory impairment in AD, and restoration of its expression can ameliorate these phenotypes in rodent models.
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TNF-α Mediates PKR-Dependent Memory Impairment and Brain IRS-1 Inhibition Induced by Alzheimer’s β-Amyloid Oligomers in Mice and Monkeys
Mychael V. Lourenco,Julia R. Clarke,Rudimar Luiz Frozza,Theresa R. Bomfim,Leticia Forny-Germano,Andre F. Batista,Luciana B. Sathler,Jordano Brito-Moreira,Olavo B. Amaral,Cesar A. Silva,Léo Freitas-Correa,Sheila Espírito-Santo,Paula Campello-Costa,Jean-Christophe Houzel,William L. Klein,Christian Hölscher,José B.C. Carvalheira,Aristóbolo M. Silva,Aristóbolo M. Silva,Licio A. Velloso,Douglas P. Munoz,Sergio T. Ferreira,Fernanda G. De Felice +22 more
TL;DR: Results reveal pathogenic mechanisms shared by AD and diabetes and establish that proinflammatory signaling mediates oligomer-induced IRS-1 inhibition and PKR-dependent synapse and memory loss.
Journal ArticleDOI
Anti-Inflammatory Effects of Resveratrol: Mechanistic Insights
TL;DR: It is highlighted how resveratrol, despite its unfavorable pharmacokinetics, can modulate the inflammatory pathways underlying those diseases, and it is identified future opportunities for the evaluation of its clinical feasibility.
Journal ArticleDOI
Alzheimer‐associated Aβ oligomers impact the central nervous system to induce peripheral metabolic deregulation
Julia R. Clarke,Natalia M. Lyra e Silva,Cláudia P. Figueiredo,Rudimar Luiz Frozza,Jose Henrique Ledo,Danielle Beckman,Carlos K. Katashima,Daniela S. Razolli,Bruno M. Carvalho,Renata Frazão,Marina A. Silveira,Felipe C. Ribeiro,Theresa R. Bomfim,Fernanda S Neves,William L. Klein,Rodrigo Medeiros,Frank M. LaFerla,José B.C. Carvalheira,Mario J.A. Saad,Douglas P. Munoz,Licio A. Velloso,Sergio T. Ferreira,Fernanda G. De Felice +22 more
TL;DR: It is shown that intracerebroventricular infusion of AD‐associated Aβ oligomers (AβOs) in mice triggered peripheral glucose intolerance, a phenomenon further verified in two transgenic mouse models of AD.