Journal ArticleDOI
Free and nanoencapsulated curcumin suppress β-amyloid-induced cognitive impairments in rats: Involvement of BDNF and Akt/GSK-3β signaling pathway
Juliana Bender Hoppe,Karine Coradini,Rudimar Luiz Frozza,Claudia M. Oliveira,André Meneghetti,Andressa Bernardi,Elisa Nicoloso Simões Pires,Ruy Carlos Ruver Beck,Christianne Gazzana Salbego +8 more
TLDR
The findings demonstrate that administration of curcumin was effective in preventing behavioral impairments, neuroinflammation, tau hyperphosphorylation as well as cell signaling disturbances triggered by Aβ in vivo, and suggest thatCur-LNC in a dose 20-fold lower presented similar neuroprotective results compared to the effective dose of free curcuming.About:
This article is published in Neurobiology of Learning and Memory.The article was published on 2013-11-01. It has received 154 citations till now. The article focuses on the topics: Curcumin & Neuroinflammation.read more
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Curcumin-Loaded Nanoparticles Potently Induce Adult Neurogenesis and Reverse Cognitive Deficits in Alzheimer’s Disease Model via Canonical Wnt/β-Catenin Pathway
Shashi Kant Tiwari,Swati Agarwal,Swati Agarwal,Brashket Seth,Brashket Seth,Anuradha Yadav,Anuradha Yadav,Saumya Nair,Priyanka Bhatnagar,Madhumita Karmakar,Manisha Kumari,L.K.S. Chauhan,Devendra Kumar Patel,Devendra Kumar Patel,Vikas Srivastava,Vikas Srivastava,Dhirendra Singh,Shailendra K. Gupta,Shailendra K. Gupta,Anurag Tripathi,Rajnish Kumar Chaturvedi,Rajnish Kumar Chaturvedi,Kailash C. Gupta,Kailash C. Gupta,Kailash C. Gupta +24 more
TL;DR: The results suggest that curcumin nanoparticles induce adult neurogenesis through activation of the canonical Wnt/β-catenin pathway and may offer a therapeutic approach to treating neurodegenerative diseases such as AD, by enhancing a brain self-repair mechanism.
Journal ArticleDOI
Nanoencapsulation of food ingredients using carbohydrate based delivery systems
TL;DR: A review of the state of the art of carbohydrate-based delivery systems for utilization in the food, pharmaceutical and other industries can be found in this paper, where the authors provide an overview of different kinds of carbohydrates used to assemble delivery systems, including starch, cellulose, pectin, guar gum, chitosan, alginate, dextrin, cyclodextrins, new sources of native gums, and their combinations and chemically modified forms.
Journal ArticleDOI
Modulation of neurotrophic signaling pathways by polyphenols
TL;DR: A better understanding of the neurotrophic effects of polyphenols and the concomitant modulations of signaling pathways is useful for designing more effective agents for management of neurodegenerative diseases.
Journal ArticleDOI
Brain-Derived Neurotrophic Factor in Alzheimer’s Disease: Risk, Mechanisms, and Therapy
Jing-Hui Song,Jin-Tai Yu,Lan Tan +2 more
TL;DR: E enlightening the detailed biological ability and complicated mechanisms of action of BDNF in the context of AD would provide a future BDNF-related remedy for AD, such as increment in the production or release of endogenous BDNF by some drugs or BDNF mimics.
Journal ArticleDOI
Effects of diet on brain plasticity in animal and human studies: mind the gap.
TL;DR: The gap in mechanistic understanding between recent findings from animal studies and those human studies reporting that these dietary factors can benefit cognition, mood, and anxiety, aging, and Alzheimer's disease is evaluated—with focus on the enhancement of structural and functional plasticity markers in the hippocampus.
References
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The Rat Brain in Stereotaxic Coordinates
George Paxinos,Charles Watson +1 more
TL;DR: This paper presents a meta-analyses of the determinants of earthquake-triggered landsliding in the Czech Republic over a period of 18 months in order to establish a probabilistic framework for estimating the intensity of the earthquake.
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Bioavailability of curcumin: problems and promises.
TL;DR: Enhanced bioavailability of curcumin in the near future is likely to bring this promising natural product to the forefront of therapeutic agents for treatment of human disease.
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Cellular survival: a play in three Akts
TL;DR: The mechanisms by which survival factors regulate the PI3K/c-Akt cascade, the evidence that activation of the PI 3K/ c-AKT pathway promotes cell survival, and the current spectrum of c- akt targets and their roles in mediating c- Akt-dependent cell survival are reviewed.
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Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment.
Robert D. Terry,Eliezer Masliah,David P. Salmon,Nelson Butters,Richard DeTeresa,Robert Hill,Lawrence A. Hansen,Robert Katzman +7 more
TL;DR: Both linear regressions and multivariate analyses correlating three global neuropsychological tests with a number of structural and neurochemical measurements performed on a prospective series of patients with Alzheimer's disease and 9 neuropathologically normal subjects reveal very powerful correlations with all three psychological assays.
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A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data.
TL;DR: A new memory test in rats, based on the differential exploration of familiar and new objects, which is comparable to memory tests currently used in man and allows interspecies comparisons.
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