Juliana L. Bernardoni

TL;DR: It is suggested that it is possible to obtain pan-specific effective antivenoms for Bothrops envenomations through immunization with venoms from only a few species of snakes, if these venoms contain protein classes that are representative of all species to which the antivenom is targeted.

TL;DR: Using a functional proteomic approach, intraspecific differences in B. atrox venom were highlighted that could impact both in the ecology of snakes but also in the treatment of snake bite patients in the region.

TL;DR: Functional distinct forms of SVMPs were found in B. neuwiedi venom that affect distinct mechanisms in the coagulation system of humans, birds and small rodents, strengthening the current hypothesis that toxin diversity enhances the possibilities of the snakes for hunting different prey or evading different predators.

TL;DR: This study broadens the current understanding about the adaptive role of the SVMPs, as well as highlights how the functional diversity of SVMP isoforms can influence clinical outcomes.