R
Richard H. Valente
Researcher at Oswaldo Cruz Foundation
Publications - 83
Citations - 1959
Richard H. Valente is an academic researcher from Oswaldo Cruz Foundation. The author has contributed to research in topics: Snake venom & Venom. The author has an hindex of 24, co-authored 74 publications receiving 1626 citations. Previous affiliations of Richard H. Valente include National Institute of Standards and Technology & Federal University of Rio de Janeiro.
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Journal ArticleDOI
Comparison of phylogeny, venom composition and neutralization by antivenom in diverse species of bothrops complex.
Leijiane F. Sousa,Carolina A. Nicolau,Carolina A. Nicolau,Pedro S. Peixoto,Juliana L. Bernardoni,Sâmella Silva de Oliveira,Sâmella Silva de Oliveira,José Antonio Portes-Junior,Rosa Helena Veras Mourão,Rosa Helena Veras Mourão,Isa Lima-dos-Santos,Ida S. Sano-Martins,Ida S. Sano-Martins,Hipócrates de Menezes Chalkidis,Richard H. Valente,Richard H. Valente,Ana M. Moura-da-Silva,Ana M. Moura-da-Silva +17 more
TL;DR: It is suggested that it is possible to obtain pan-specific effective antivenoms for Bothrops envenomations through immunization with venoms from only a few species of snakes, if these venoms contain protein classes that are representative of all species to which the antivenom is targeted.
Journal ArticleDOI
Amino acid sequence and crystal structure of BaP1, a metalloproteinase from Bothrops asper snake venom that exerts multiple tissue-damaging activities.
Leandra Watanabe,John D. Shannon,Richard H. Valente,Richard H. Valente,Alexandra Rucavado,Alberto Alape-Girón,Aura S. Kamiguti,R. David G. Theakston,Jay W. Fox,José María Gutiérrez,Raghuvir K. Arni +10 more
TL;DR: Sequence and structural comparisons of hemorrhagic and nonhemorrhagic P‐I metalloproteinases from snake venoms revealed differences in several regions, which may influence the interaction of these enzymes with physiologically relevant substrates in the extracellular matrix.
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Natterins, a new class of proteins with kininogenase activity characterized from Thalassophryne nattereri fish venom.
Geraldo S. Magalhães,Mônica Lopes-Ferreira,Inácio L.M. Junqueira-de-Azevedo,Patrick Jack Spencer,Mariana S. Araujo,Fernanda C. V. Portaro,L. Ma,Richard H. Valente,Richard H. Valente,L. Juliano,Jay W. Fox,Paulo L. Ho,Ana M. Moura-da-Silva +12 more
TL;DR: A novel family of proteins with kininogenase activity and unique primary structure was characterized using combined pharmacological, proteomic and transcriptomic approaches of Thalassophryne nattereri fish venom, and the complete sequences of natterins did not show any significant similarity with already described tissue kallikreins, Kininogenases or any proteinase.
Journal ArticleDOI
Search engine processor: Filtering and organizing peptide spectrum matches.
Paulo C. Carvalho,Juliana de Saldanha da Gama Fischer,Tao Xu,Daniel Cociorva,Tiago Santana Balbuena,Richard H. Valente,Jonas Perales,John R. Yates,Valmir C. Barbosa +8 more
TL;DR: By using the semi‐labeled decoy approach for benchmarking, it is shown that SEPro significantly outperforms a commercially available competitor.
Journal ArticleDOI
Bothrops insularis venomics: a proteomic analysis supported by transcriptomic-generated sequence data.
Richard H. Valente,Patricia Ramos Guimarães,Magno Junqueira,Ana G.C. Neves-Ferreira,Márcia Regina Soares,Alex Chapeaurouge,Monique R.O. Trugilho,Ileana R. León,Surza Lucia Gonçalves da Rocha,Surza Lucia Gonçalves da Rocha,Ana Lucia Oliveira-Carvalho,Luciana S. Wermelinger,Denis L. S. Dutra,Luciana I. Leão,Inácio L.M. Junqueira-de-Azevedo,Paulo L. Ho,Russolina B. Zingali,Jonas Perales,Gilberto B. Domont +18 more
TL;DR: This study provides a preliminary reference map for proteins and peptides present in Bothrops insularis whole venom establishing the basis for comparative studies of other venom proteomes which could help the search for new drugs and the improvement of venom therapeutics.