José Antonio Portes-Junior

TL;DR: It is suggested that it is possible to obtain pan-specific effective antivenoms for Bothrops envenomations through immunization with venoms from only a few species of snakes, if these venoms contain protein classes that are representative of all species to which the antivenom is targeted.

TL;DR: Using a functional proteomic approach, intraspecific differences in B. atrox venom were highlighted that could impact both in the ecology of snakes but also in the treatment of snake bite patients in the region.

TL;DR: Analysis of individual transcripts and venom protein isoforms produced by specimens of a venomous snake (Bothrops atrox), from the Brazilian Amazon rainforest, revealed that transcriptional and translational mechanisms contribute to venom phenotypic variation.

TL;DR: The cloning of a PLD from L. gaucho venom gland is shown, named LgRec1, which was successfully expressed in a bacterial system and demonstrated to be highly immunogenic and antibodies raised against this recombinant toxin inhibited local reaction and dermonecrosis elicited by L. Gaucho whole venom.

TL;DR: Some published evidence is discussed that posit that processing and post-translational modifications are great contributors for the generation of functional diversity and for maintaining latency or inactivation of enzymes belonging to this relevant family of venom toxins.