Juliane G. Strauss

TL;DR: It is reported that a second enzyme, adipose triglyceride lipase (ATGL), catalyzes the initial step in triglyceride hydrolysis, and it is interesting that ATGL contains a “patatin domain” common to plant acyl-hydrolases.

TL;DR: Exercise of functional CGI-58 in CDS fibroblasts restores lipolysis and reverses the abnormal TG accumulation typical for CDS, establishing an important biochemical function for CGI- 58 in the lipolytic degradation of fat.

TL;DR: Adipose triglyceride lipase represents a novel type of ‘patatin domain-containing’ triacylglycerol hydrolase that is more closely related to plant lipases than to other known mammalian metabolic triacyLglycerl hydrolases, and requires a revision of the concept that hormone-sensitive lipase is the only enzyme involved in the lipolysis of adipose tissue triglycerides.

TL;DR: It is demonstrated that HSL deficiency markedly affects the metabolism of TG-rich lipoproteins by the coordinate down-regulation of VLDL synthesis and up- regulation of LPL in muscle and white adipose tissue, which result in an “anti-atherogenic” lipoprotein profile.

TL;DR: Results establish that in the absence of HSL, the reduced NEFA production is counteracted by a drastic reduction of NEFA reesterification that provides sufficient quantities ofNEFA for release into the circulation.